Browsing Faculty of Arts and Sciences by Title
Now showing items 10129-10148 of 24328
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I Go, You Go: Searching for Strength and Self in the American Gym
(2016-05-12)This ethnography is based on 48 months of detailed participation, interviews, and observation with active gymgoers at three middle-class gyms in Chicago. It is a study of a particular social institution that, despite its ... -
I Got More Data, My Model is More Refined, but My Estimator is Getting Worse! Am I Just Dumb?
(Informa UK (Taylor & Francis), 2013)Possibly, but more likely you are merely a victim of conventional wisdom. More data or better models by no means guarantee better estimators (e.g., with a smaller mean squared error), when you are not following probabilistically ... -
I Spit Upon the Noble: The Epicurean Critique of Love of Honor and the Origins of Modernity
(2013-10-18)Modern liberal democracies regard "pursuit of happiness" as one of the fundamental rights that governments are instituted to protect - but modern political thought has comparatively little to say about happiness itself. ... -
I Want to Go to the Future Please: Jenny Holzer and the End of a Century
(2013-03-18)The task of this dissertation is to assess the historical conditions that permitted Jenny Holzer to formulate a practice premised on language and conceptions of public space to break from historical avant-garde and ... -
“I Whisper Into the Radio Ear”: Radio Sound and Russian Modernist Poetics
(2016-09-12)In 1924, the Soviet “electrification” was followed by “radiofication,” a gradual introduction of broadcast radio that led to novel forms of newscasts, political propaganda, and creative formats. This dissertation is the ... -
"I Worship Black Gods": Formation of an African American Lucumi Religious Subjectivity
(2015-05-17)In 1959, Christopher Oliana and Walter “Serge” King took a historic journey to pre-revolutionary Cuba that would change the religious trajectory of numerous African Americans, particularly in New York City. They became the ... -
I. Chiral Squaramide Catalysts for Lewis Acid Activation in Asymmetric Catalysis II. Catalytic, Stereoselective Difluorination Reactions
(2016-12-13)In Chapter 1, we report the observation that chiral squaramide hydrogen-bond (H-bond) donor catalysts act cooperatively with trialkylsilyl trifluoromethanesulfonates (silyl triflates) to promote enantioselective (4+3) ... -
I. Completion of a Total Synthesis of Peloruside A. II. Studies toward the Total Synthesis of Spiro-Prorocentrimine
(2013-03-05)I. Completion of a Total Synthesis of Peloruside A: The completion of a 22 step synthesis of the marine natural product peloruside A is presented. The second generation strategy cuts 10 steps from longest linear sequence ... -
I. Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis II. Development of a Practical Method for the Synthesis of Highly Enantioenriched Trans-1,2-Amino Alcohols
(2013-08-21)A highly enantioselective acylation of silyl ketene acetals with acyl fluorides was developed to generate useful α,α-disubstituted butyrolactone products in high yield and excellent enantioselectivities. This transformation ... -
I. Engaging Cationic Intermediates in Asymmetric Catalysis: Enantioselective Reactions of Carbenium Ions and N,N-Dialkyliminium Ions II. Enantioselective Catalysis of the Cope-Type Hydroamination by H-Bond Donors
(2013-09-16)The research described here explores the ability of dual H-bond donor catalysts to induce asymmetry in a variety of synthetically useful transformations that proceed via diverse reactive intermediates. In Chapters 1-3, ... -
I. Stereoselective Construction of Polycyclic Architectures: Enantioselective Catalytic Transannular Ketone-Ene Reactions and an Enantioselective Total Synthesis of (+)-Reserpine II. Synthesis of Chiral Bisthioureas for Anion-Abstraction Catalysis
(2013-10-18)The research presented herein explores three aspects of asymmetric catalysis: (1) the development of new catalytic enantioselective reactions, (2) the application of stereoselective catalysis to natural product total ... -
I. Synthesis of C4-Modified Tetracyclines II. Aldolizations of Pseudoephenamine Glycinamide and Applications Toward the Synthesis of Monocyclic β-Lactam Antibiotics
(2015-05-14)Part one of this thesis describes the production of C4-modified tetracycline derivatives. Our synthetic strategy originally targeted SF2575, a C4-oxygenated tetracycline analog with antiproliferative properties, but was ... -
I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
(2014-02-25)Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ... -
IAP Inhibitors as Novel Immune Adjuvants for Scaffold Based Cancer Vaccines
(2015-05-14)Inhibitors of apoptosis (IAP) antagonists are nearing approval as promising new candidates for cancer therapy, particularly for solid tumors. Previous work had uncovered the ability of the monomer version of this drug to ... -
Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells
(Impact Journals LLC, 2015)Through comprehensive comparison study, we found that ibrutinib, a clinically approved covalent BTK kinase inhibitor, was highly active against EGFR (L858R, del19) mutant driven NSCLC cells, but moderately active to the ... -
iBundle: An Efficient Ascending Price Bundle Auction
(Association for Computing Machinery, 1999)Standard auction mechanisms often break down in important e-commerce applications, where agents demand bundles of complementary resources, i.e. "I only want B if I also get A". This paper describes iBundle, an ascending-price ... -
The IC 133 Water Vapor Maser in the Galaxy M33: A Geometric Distance
(IOP Publishing, 2004)We report on the results of a 14 year long VLBI study of proper motions in the IC 133 H2O maser source in the galaxy M33. The method of Ordered Motion Parallax was used to model the 3-dimensional structure and dynamics of ... -
ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast Cancer
(Ivyspring International Publisher, 2016)Lipocalin 2 (Lcn2) is a promising therapeutic target as well as a potential diagnostic biomarker for breast cancer. It has been previously shown to promote breast cancer progression by inducing the epithelial to mesenchymal ... -
Ice Elevation Near the West Antarctic Ice Sheet Divide During the Last Glaciation
(American Geophysical Union, 2007)Interior ice elevations of the West Antarctic Ice Sheet (WAIS) during the last glaciation, which can serve as benchmarks for ice-sheet models, are largely unconstrained. Here we report past ice elevation data from the Ohio ... -
Ice Lithography for Nano-Devices
(American Chemical Society, 2010)We report the successful application of a new approach, ice lithography (IL), to fabricate nanoscale devices. The entire IL process takes place inside a modified scanning electron microscope (SEM), where a vapor-deposited ...