Browsing Faculty of Arts and Sciences by Title
Now showing items 13254-13273 of 24540
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Mechanisms underlying subcellular targeting specificities: case studies in pharmacological actions of nitrogen-containing-bisphosphonates and glia-mediated synapse elimination
(2021-04-22)A fundamental phenomenon in biology is the organization of cells into subcellular compartments and structures that contain distinct molecules and perform unique functions. Studying the mechanisms by which biological events ... -
A Mechanistic Approach Towards Highly Efficient Anion-Binding Catalysts
(2016-09-14)Over the past decade, organocatalysis has emerged as a thriving area of research in the field of small-molecule asymmetric catalysis. In this context, the development of highly efficient catalysts—i.e. TON ≥ 1000, TOF ≥ ... -
Mechanistic approaches to understanding and predicting mammalian space use: Recent advances, future directions
(Oxford University Press (OUP), 2012)The coming of age of global positioning system telemetry, in conjunction with recent theoretical innovations for formulating quantitative descriptions of how different ecological forces and behavioral mechanisms shape ... -
Mechanistic Basis for High Reactivity of (salen)Co–OTs in the Hydrolytic Kinetic Resolution of Terminal Epoxides
(American Chemical Society, 2012)The (salen)Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of terminal epoxides is a bimetallic process with a rate controlled by partitioning between a nucleophilic (salen)Co–OH catalyst and a Lewis acidic (salen)Co–X ... -
The Mechanistic Basis of Dynein Microtubule Binding and Its Regulation
(2015-01-22)Eukaryotic cells use a diverse toolbox of cytoskeletal motors to transport and position cellular materials in space and time. Two microtubule-based motors—kinesin and dynein—transport organelles, RNA and protein cargos ... -
Mechanistic Determinants of the Directionality and Energetics of Active Export by a Heterodimeric ABC Transporter
(Nature Publishing Group, 2014)The ATP-binding cassette (ABC) transporter associated with antigen processing (TAP) participates in immune surveillance by moving proteasomal products into the endoplasmic reticulum (ER) lumen for major histocompatibility ... -
Mechanistic dissection of direct MEF2C disruption and long-range regulatory alterations within the chromosome 5q14.3 locus as strong effect drivers of neurodevelopmental disorders
(2022-01-26)Direct and indirect point mutations and structural variants that cause haploinsufficiency of MEF2C have been implicated as causes of neurodevelopmental disorders (NDDs). However, the impact of these mutations on ... -
Mechanistic Dissection of Substrate Recruitment by Ubiquitin Ligases
(2023-09-06)Protein homeostasis is an essential process that needs to be tightly regulated to maintain a delicate balance between protein synthesis and protein degradation. The Ubiquitin Proteasome System (UPS) serves as a fundamental ... -
Mechanistic Home Range Models and Resource Selection Analysis: A Reconciliation and Unification
(Ecological Society of America, 2008)In the three decades since its introduction, resource selection analysis (RSA) has become a widespread method for analyzing spatial patterns of animal relocations obtained from telemetry studies. Recently, mechanistic home ... -
Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics
(Landes Bioscience, 2014)The human gut microbiota plays a key role in pharmacology, yet the mechanisms responsible remain unclear, impeding efforts toward personalized medicine. We recently identified a cytochrome-encoding operon in the common gut ... -
Mechanistic Insights into the Conformational Regulation of Pro-Apoptotic BAX
(2022-03-17)BCL-2 family proteins are apoptotic regulators that control the critical balance between cellular life and death at the level of the mitochondrion. BAX is a principal executioner of apoptosis, transforming from a latent ... -
Mechanistic Studies in Enantioselective Ion-Pairing Catalysis With Dual Hydrogen-Bond Donors
(2016-12-20)Enantioselective ion-pairing catalysis has emerged as a powerful strategy for controlling the stereochemical outcomes of reactions proceeding through charged intermediates. While ion pairing between chiral ionic catalysts ... -
Mechanistic studies of cation catalysis in nonenzymatic RNA primer extension
(2022-06-06)The origin of life is believed to have centered around RNA acting as both genetic information and catalyst. Several decades into research around the RNA world hypothesis, however, life has yet to be created synthetically. ... -
Mechanistic Studies of First-Row Metal-Mediated and -Catalyzed Reactions
(2018-04-10)First-row transition metals find growing applications in organic transformations due to their abundance and low cost. In addition, the difference in redox states of first-row metals to those of second or third row metals ... -
Mechanistic studies of lipopolysaccharide transport in Gram-negative bacteria
(2021-07-12)Gram-negative bacterial infections are a significant threat to human health due to increasing resistance to all classes of clinically used antibiotics. Gram-negative bacteria are extremely challenging to kill because of ... -
Mechanistic Studies of Polycomb Group Proteins
(2012-12-20)Most cells within multicellular organisms contain the same genetic information, yet the appropriate tissue-specific expression of genes is required for the proper formation of adult tissues. Genes can either be “turned on” ... -
Mechanistic Studies of SecY-Mediated Protein Translocation in Intact Escherichia coli Cells
(2013-02-12)During the synthesis of secretory and membrane proteins, polypeptides move through a universally conserved protein-conducting channel, formed by the Sec61/SecY complex that is located in the eukaryotic endoplasmic reticulum ... -
Mechanistic Studies of the Microtubule-Based Motors Dynein and Kinesin-8
(2015-05-20)The precise delivery and organization of intracellular factors in space and time relies on a set of molecules that move along and regulate the dynamics of cytoskeletal filaments. The two families of microtubule-based ... -
Mechanistic Studies of Vertebrate Hedgehog Signaling
(2013-03-14)Metazoans use Hedgehog signaling to direct many stages of embryonic development, and deregulation of this pathway is implicated in many types of cancer. I investigated several steps of Hedgehog pathway transduction that ... -
Mechanistic Understanding of PH Domain-Mediated Autoinhibition and Oncogenic Activation of Akt
(2022-06-06)The protein kinase Akt plays a critical role in cell survival and proliferation, and its over-activation can drive cancer. The activity of Akt is delicately regulated by post-translational modifications (PTMs) and its ...