Browsing Faculty of Arts and Sciences by Title
Now showing items 17247-17266 of 24540
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Productivity Change in Health Care
(American Economic Association, 2001) -
Professional Disequilibrium: Conflict of Interest in Economics
(Oxford University Press, 2014-03-03)<p>The economics profession lags behind others in adopting policies to regulate conflict of interest. The purposes of conflict of interest regulations, which are often misunderstood, are to minimize bias in research and ... -
Profile-Based Optimization with Statistical Profiles
(1997)An important barrier to the use of profile-based optimization is the generation of high-quality profile data. In this paper we describe our experience with a prototype system for continuous and automatic generation of ... -
Profiles in Science for Science Librarians: Paul Callistus Sereno
(Informa UK Limited, 2017)Paul Sereno is one of the better-known paleontologists of our time. His expeditions have taken him around the world, and he has discovered new dinosaurs – and other ancient creatures – in places as far-flung as Argentina, ... -
Profiles in Science for Science Librarians: Ruth Hubbard, Scientist and Social Activist
(Informa UK Limited, 2017-12-13)Ruth Hubbard (1924-2016) is known for her groundbreaking research on the biochemistry and photochemistry of the eye and for her social activism. In 1974 she was the first woman to be tenured in biology at Harvard. In ... -
Profiles of Everyday Thought Suppression
(2014-06-06)The present research assessed whether levels of depression, anxiety and worry, obsessive-compulsive distress, and psychopathy were differentially related to distinct thought suppression profiles. As a means to achieving ... -
Profiling and Improving the Specificity of Site-Specific Nucleases
(2014-06-06)Programmable site-specific endonucleases are useful tools for genome editing and may lead to novel therapeutics to treat genetic diseases. TALENs can be designed to cleave chosen DNA sequences. To better understand TALEN ... -
Profiling originalism
(Columbia Law Review Association, Inc., 2011)Originalism is a subject of both legal and political discourse, invoked not just in law review scholarship but also in popular media and public discussion. This Essay presents the first empirical study of public attitudes ... -
Progenitor Cell Diversity and Function in the Developing Cerebral Cortex
(2015-05-07)The human cerebral cortex, the largest structure of our brain, is the seat of our most highly developed cognitive functions. Its normal development, proper function, and ultimate size depend on a precisely controlled balance ... -
Prognostic Factors in Advanced Cancer Patients: Evidence-Based Clinical Recommendations—A Study by the Steering Committee of the European Association for Palliative Care
(American Society of Clinical Oncology (ASCO), 2005)Purpose To offer evidence-based clinical recommendations concerning prognosis in advanced cancer patients. Methods A Working Group of the Research Network of the European Association for Palliative Care identified ... -
A prognostic model of the sea-ice floe size and thickness distribution
(Copernicus GmbH, 2015)Sea ice exhibits considerable seasonal and longer-term variations in extent, concentration, thickness, and age, and is characterized by a complex and continuously changing distribution of floe sizes and thicknesses, ... -
Prognostication and Bioethics
(Massachusetts Institute of Technology Press (MIT Press), 1999) -
The Program of Gene Transcription for a Single Differentiating Cell Type During Sporulation in Bacillus Subtilis
(Public Library of Science, 2004)Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that undergoes a 5-h program of differentiation. The program is governed by a hierarchical cascade consisting of the transcription factors: ... -
Programed Death is Favored by Natural Selection in Spatial Systems
(American Physical Society, 2015)Standard evolutionary theories of aging and mortality, implicitly based on mean-field assumptions, hold that programed mortality is untenable, as it opposes direct individual benefit. We show that in spatial models with ... -
Programmable biofilm-based materials from engineered curli nanofibres
(Nature Publishing Group, 2014)The significant role of biofilms in pathogenicity has spurred research into preventing their formation and promoting their disruption, resulting in overlooked opportunities to develop biofilms as a synthetic biological ... -
A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells
(Oxford University Press, 2016)We describe the development of ‘recCas9’, an RNA-programmed small serine recombinase that functions in mammalian cells. We fused a catalytically inactive dCas9 to the catalytic domain of Gin recombinase using an optimized ... -
Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
(Springer Science and Business Media LLC, 2021-12-09)The targeted deletion, replacement, integration or inversion of genomic sequences could be used to study or treat human genetic diseases, but existing methods typically require double-strand DNA breaks (DSBs) that lead to ... -
Programmable diagnostic devices made from paper and tape
(Royal Society of Chemistry (RSC), 2010)This paper describes three-dimensional microfluidic paper-based analytical devices (3-D µPADs) that can be programmed (postfabrication) by the user to generate multiple patterns of flow through them. These devices are ... -
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
(2016)Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction.1,2 Although most genetic diseases arise from point mutations, current approaches to point ... -
Programmable Potentials: Approximate N-body potentials from coarse-level logic
(Nature Publishing Group, 2016)This paper gives a systematic method for constructing an N-body potential, approximating the true potential, that accurately captures meso-scale behavior of the chemical or biological system using pairwise potentials coming ...