Browsing Faculty of Arts and Sciences by Title
Now showing items 4857-4876 of 24540
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Development and validation of computational models for efficient design of biological sequences
(2022-01-10)There is a huge surge of interest in designing a wide variety of proteins to use as molecular research tools and biotherapeutics - promising to revolutionize our capacity to design what we need at will. This is particularly ... -
Development and Validation of Migration Assay for Cellular Backpacks Adhered to Human and Murine Monocytes for Targeted Drug-Delivery
(2022-06-03)The Mitragotri Lab has been developing immune cell-based therapies to improve drug targeting and accumulation, particularly to cross the blood-brain barrier for the treatment of traumatic brain injury. We use cellular ... -
Development in the acoel Hofstenia miamia and the embryonic origins of stem cells
(2022-06-06)Many animals across the metazoan tree of life are capable of whole-body regeneration, or the regeneration of entire body axes. Notably, whole body regeneration is often mediated by a population of pluripotent stem cells ... -
Development of a Broad-Host-Range SacB-Based Vector for Unmarked Allelic Exchange
(BioMed Central, 2008)Background: Although genome sequences are available for an ever-increasing number of bacterial species, the availability of facile genetic tools for physiological analysis have generally lagged substantially behind traditional ... -
Development of a grid-independent GEOS-chem chemical transport model as an atmospheric chemistry module for Earth System Models
(Copernicus GmbH, 2014)The GEOS-Chem global chemical transport model (CTM), used by a large atmospheric chemistry research community, has been re-engineered to also serve as an atmospheric chemistry module for Earth System Models (ESMs). This ... -
Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections
(Public Library of Science, 2015)Plasmodium vivax, one of the five species of Plasmodium parasites that cause human malaria, is responsible for 25–40% of malaria cases worldwide. Malaria global elimination efforts will benefit from accurate and effective ... -
Development of a Trajectory Model for the Analysis of Stratospheric Water Vapor
(2016-05-14)To study stratospheric water vapor, a new trajectory model was created. The model is built from first principles specific to stratospheric motion and can run on any gridded dataset, making it more versatile than current ... -
The Development of Altruistic Behavior: Helping in Children and Chimpanzees
(Johns Hopkins University Press, 2014-06-10) -
Development of an Insertional Expression Vector System for Methylobacterium Extorquens AM1 and Generation of Null Mutants Lacking mtdA and/or fch
(Society for General Microbiology, 2004)Over the past few years, the genetic 'toolkit' available for use with <i>Methylobacterium extorquens</i> AM1 has expanded significantly. Here a further advance is presented and demonstrated, an insertional expression system ... -
Development of an Optimized Medium, Strain and High-Throughput Culturing Methods for Methylobacterium extorquens
(Public Library of Science, 2013)Methylobacterium extorquens strains are the best-studied methylotrophic model system, and their metabolism of single carbon compounds has been studied for over 50 years. Here we develop a new system for high-throughput ... -
Development of Bioinformatics Solutions for Single-cell Transcriptomics and Novel Codec System for Robust DNA-based Data Storage
(2020-11-23)With the unprecedented wealth of biological and biomedical data generated, bioinformatics has shaped our understandings in life science through various applications: from the de novo assembly to pathway network analysis ... -
The development of bioresorbable composite polymeric implants with high mechanical strength
(Springer Nature, 2017) -
Development of bipolar interneuron subtypes within the retinal space-time continuum
(2022-01-18)Development of the retina requires precise production of more than 100 neuronal subtypes. How does such diversity emerge during development at the perfect time and place to create functional circuitry? Recent molecular ... -
The Development of Character Judgments From Faces
(2015-03-30)First impressions play a central role in human social interaction. In particular, the face is a rich source of information that perceivers use in making both initial and lasting character judgments. Despite the large and ... -
The Development of Chemical and Computational Tools to Study Transcriptional Regulation in Cancer
(2015-05-01)Eukaryotic gene regulation is a complex process requiring the action of many multicomponent complexes in the cell. Specific inhibitors of chromatin-associated factors allow the functional study of protein domains without ... -
Development of Chemical Tools to Investigate Colibactin, a Genotoxin from the Human Microbiota
(2022-11-23)The bacterial genotoxin colibactin is produced by certain commensal and pathogenic strains of E. coli and other Proteobacteria and may be a key driver of colorectal cancer (CRC) development. Colibactin induces mutations ... -
Development of CoraFluors: A Versatile, Target-agnostic Assay Technology Platform Optimized for Chemical Biology Research
(2022-11-23)Biology uses strategic, coordinated proximity events to orchestrate complex cellular pathways essential to homeostasis, survival, and propagation. The interrogation of biological systems with chemogenomic approaches has ... -
Development of Earth-Abundant and Non-Toxic Thin-Film Solar Cells
(2014-12-08)Although solar energy is the most abundant energy resource available, photovoltaic solar cells must consist of sufficiently abundant and environmentally friendly elements, for scalable low-cost production to provide a major ... -
Development of Earth-Abundant Tin(II) Sulfide Thin-Film Solar Cells by Vapor Deposition
(2013-09-18)To sustain future civilization, the development of alternative clean-energy technologies to replace fossil fuels has become one of the most crucial and challenging problems of the last few decades. The thin film solar cell ... -
Development of Enhanced Base Editors and Prime Editors through Protein Engineering and Directed Evolution
(2023-06-01)Cytosine base editors (CBEs), adenine base editors (ABEs), and prime editors have already made tremendous impacts in the basic research community and are poised to transform medicine. However, to allow precision genome ...