Browsing Faculty of Arts and Sciences by Title
Now showing items 4876-4895 of 24524
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Development of Enhanced Base Editors and Prime Editors through Protein Engineering and Directed Evolution
(2023-06-01)Cytosine base editors (CBEs), adenine base editors (ABEs), and prime editors have already made tremendous impacts in the basic research community and are poised to transform medicine. However, to allow precision genome ... -
Development of face recognition: A maturational component?
(American Psychological Association (APA), 1980)Assessed the development in approximately 160 6–16 yr old Ss of the ability to encode unfamiliar faces. Performance improved markedly between ages 6 and 10 and then remained at a fixed level or actually declined for several ... -
Development of high frequency and wide bandwidth Johnson noise thermometry
(AIP Publishing, 2015)We develop a high frequency, wide bandwidth radiometer operating at room temperature, which augments the traditional technique of Johnson noise thermometry for nanoscale thermal transport studies. Employing low noise ... -
Development of high-throughput imaging-based single cell genotype-phenotype mapping platforms
(2023-06-01)This thesis proposes a novel screening method for genotype-phenotype mapping that combines microfluidic chips with chemical or molecular biology assays, enabling accurate and high-throughput time-lapse phenotype-genotype ... -
Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
(2013-10-17)The human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined ... -
The Development of Implicit Attitudes: Evidence of Race Evaluations From Ages 6 and 10 and Adulthood
(SAGE Publications, 2006)To understand the origin and development of implicit attitudes, we measured race attitudes in White American 6-year-olds, 10-year-olds, and adults by first developing a child-oriented version of the Implicit Association ... -
The Development of Implicit Intergroup Cognition
(Elsevier, 2008)Challenging the view that implicit social cognition emerges from protracted social learning, research now suggests that intergroup preferences are present at adultlike levels in early childhood. Specifically, the pattern ... -
Development of in situ sulfur four-isotope analysis with multiple Faraday cup detectors by SIMS and application to pyrite grains in a Paleoproterozoic glaciogenic sandstone
(Elsevier BV, 2014)An in situ sulfur four-isotope analysis technique with multiple Faraday cup detectors by ion microprobe was developed and applied to detrital pyrite grains in ~2.4 Ga glaciogenic sandstone from the Meteorite Bore Member ... -
Development of Iron Complex-based Aqueous Redox Flow Batteries for Large-scale Energy Storage
(2023-05-11)The world's reliance on fossil fuels has led to significant environmental problems and economic costs. Consequently, the global economy has made it a top priority to transition to clean energy. Although renewable energy ... -
The development of language and abstract concepts: The case of natural number.
(American Psychological Association (APA), 2008)What are the origins of abstract concepts such as "seven," and what role does language play in their development? These experiments probed the natural number words and concepts of 3-year-old children who can recite number ... -
Development of Methods for Cancer Genome Analysis and Clinical Applications
(2022-06-06)Cancer, a disease with increasing morbidity and mortality, was responsible for almost 20 million new cases and 10 million deaths worldwide in 2020, becoming one of the most significant public health issues of our time. ... -
Development of Methods for Protein Delivery and the Directed Evolution of Recombinases
(2014-10-22)As a class, protein-based therapeutics offer tremendous advantages over traditional small molecule drugs. Due to their sizes and folding energies, proteins are ideal for catalyzing chemical reactions, and can bind tightly ... -
Development of Methods that Mimic, Measure, and Detect Evasion of the Adaptive Immune System
(2021-10-27)The ability of the adaptive immune system to generate incredible genetic diversity in response to environmental stimuli provides both a unique challenge to develop methods that can comprehensively analyze immune repertoires, ... -
Development of molecular glue degraders as probes and therapeutic agents
(2023-05-12)Development of molecular glue degraders as probes and therapeutic agents Immunomodulatory drugs (IMiDs) function as molecular glues between the E3 ligase substrate receptor cereblon (CRBN) and protein substrates. The ... -
Development of New Tools for Single-Molecule Force Spectroscopy & The Application of these Tools to Mapping the Role of Force Directionality in the Actin Mechanome
(2015-09-28)Actin filaments serve as a hub of focal adhesion-based mechanotransduction network in a wide variety of cell types. In this role filaments and networks of filaments are exposed to forces in a range of directions and ... -
The Development of Novel Spectroscopic Tools to Probe Free Radical Chemistry in the Troposphere
(2016-05-17)The oxidizing capacity of the atmosphere regulates both the longwave and shortwave radiation budgets holding our planet in equilibrium. As planetary conditions continue to shi , insights into the oxidation pathways determining ... -
Development of nucleic acid detection methods for object provenance and viral diagnostics
(2021-11-16)Starting with the discovery of DNA structure, advances in molecular and systems biology in the past few decades have propelled nucleic acid amplification and detection technologies with far-reaching applications including ... -
Development of photonic crystal cavities to enhance point defect emission in silicon carbide
(2017-09-07)Silicon carbide (SiC) is a semiconductor with a long history of use in a range of fields, finding applications in optoelectronics, high-power electronic devices (like field-effect transistors), and microelectromechanical ... -
The Development of Political Activists: A Model of Early Learning
(Wiley-Blackwell, 1986)An analysis of panel data reveals the unique importance of early learning to the development of political activism among Americans. A combination of two learning models-- the frequently used crystallization model and the ... -
Development of potent in vivo mutagenesis plasmids with broad mutational spectra
(Nature Pub. Group, 2015)Methods to enhance random mutagenesis in cells offer advantages over in vitro mutagenesis, but current in vivo methods suffer from a lack of control, genomic instability, low efficiency and narrow mutational spectra. Using ...