Now showing items 5200-5219 of 24465

    • Discovery of a Small Molecule That Inhibits D-Alanylation of Teichoic Acids in Staphylococcus Aureus 

      Pasquina, Lincoln Wain (2015-05-12)
      The Staphylococcus aureus cell envelope is a large, complex structure essential for cell shape and protection from the environment. It consists of membrane lipids, glycan polymers, and proteins, many of which have not been ...
    • Discovery of a Small-Molecule Probe for V-ATPase Function 

      Aldrich, Leslie N.; Kuo, Szu-Yu; Castoreno, Adam B.; Goel, Gautam; Kuballa, Petric; Rees, Matthew G.; Seashore-Ludlow, Brinton A.; Cheah, Jaime H.; Latorre, Isabel J.; Schreiber, Stuart L.; Shamji, Alykhan F.; Xavier, Ramnik J. (American Chemical Society, 2015)
      Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been ...
    • Discovery of a Wide Binary Brown Dwarf Born in Isolation 

      Luhman, K. L.; Mamajek, E. E.; Allen, P. R.; Muench, August A.; Finkbeiner, Douglas (IOP Publishing, 2009)
      During a survey for stars with disks in the Taurus star-forming region using the Spitzer Space Telescope, we have discovered a pair of young brown dwarfs, FU Tau A and B, in the Barnard 215 dark cloud. They have a projected ...
    • Discovery of a z = 4.93, X-Ray-selected Quasar by the Chandra Multiwavelength Project (ChaMP) 

      Silverman, John D.; Green, Paul J.; Kim, Dong-Woo; Wilkes, Belinda Jane; Cameron, Robert A.; Morris, David; Dosaj, Anil; Smith, Chris; Infante, Leopoldo; Smith, Paul S.; Jannuzi, Buell T.; Mathur, Smita (IOP Publishing, 2002)
      We present X-ray and optical observations of CXOMP J213945.0-234655, a high-redshift (z = 4.93) quasar discovered through the Chandra Multiwavelength Project (ChaMP). This object is the most distant X-ray-selected quasar ...
    • Discovery of Abundant Hydrothermal Venting on the Ultra-Slow Spreading Gakkel Ridge, Arctic Ocean 

      Graham, D.W.; German, C.R.; Muhe, R.; Dick, H.J.B.; Langmuir, Charles; Snow, J.E.; Connelly, D.P.; Baker, E.T.; Michael, P.J.; Edmonds, H.N. (Nature Publishing Group, 2003)
      Submarine hydrothermal venting along mid-ocean ridges is an important contributor to ridge thermal structure(1), and the global distribution of such vents has implications for heat and mass fluxes(2) from the Earth's crust ...
    • Discovery of an Outflow from Radio Observations of the Tidal Disruption event ASASSN-14li 

      Alexander, K. D.; Berger, Edo; Guillochon, J.; Zauderer, B. A.; Williams, Peter Kelsey George (American Astronomical Society, 2016)
      We report the discovery of transient radio emission from the nearby optically-discovered TDE ASASSN-14li (distance of 90 Mpc), making it the first typical TDE detected in the radio, and unambiguously pointing to the formation ...
    • Discovery of an Ultraviolet Counterpart to an Ultrafast X-Ray Outflow in the Quasar PG 1211+143 

      Kriss, Gerard; Lee, Julia; Danehkar, Ashkbiz; Nowak, Michael; Fang, Taotao; Hardcastle, Martin; Neilsen, Joseph; Young, Andrew (American Astronomical Society, 2018-02-02)
      We observed the quasar PG 1211+143 using the Cosmic Origins Spectrograph on the Hubble Space Telescope in 2015 April as part of a joint campaign with the Chandra X-ray Observatory and the Jansky Very Large Array. Our ...
    • Discovery of Associated Absorption Lines in an X-Ray Warm Absorber:[ITAL]Hubble Space Telescope[/ITAL] Observations of PG 1114+445 

      Mathur, Smita; Wilkes, Belinda Jane; Elvis, Martin S. (IOP Publishing, 1998)
      The unified picture of X-ray/UV absorbers offers a unique opportunity to probe the nuclear environment of active galactic nuclei. To test the unified absorber scenario and to understand the physical properties of the ...
    • Discovery of bioactive lipids and lipid pathways in cell death and disease 

      Zhang, Tejia (2014-06-06)
      Apoptosis is an intricately regulated cellular process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose ...
    • Discovery of cancer vulnerabilities in gene expression regulation pathway 

      Zhou, Chen (2023-12-11)
      Cancer is one of the leading causes of death and many researchers are working on combating cancer. Despite significant progress in cancer therapeutics, many cancers still lack targeted therapies and new ways to enhance the ...
    • Discovery of Candidate H2O Disk Masers in Active Galactic Nuclei and Estimations of Centripetal Accelerations 

      Greenhill, Lincoln Jared; Kondratko, Paul T.; Moran, James M.; Tilak, Avanti (IOP Publishing, 2009)
      Based on spectroscopic signatures, about one-third of known H2O maser sources in active galactic nuclei (AGNs) are believed to arise in highly inclined accretion disks around central engines. These “disk maser candidates” ...
    • Discovery of Collimated Bipolar Outflows in the Planetary Nebula TH 2-A 

      Danehkar, Ashkbiz (IOP Publishing, 2015)
      We present a comprehensive set of spatially resolved, integral field spectroscopic mapping of the Wolf-Rayet planetary nebula Th 2-A, obtained using the Wide Field Spectrograph on the Australian National University 2.3-m ...
    • Discovery of eight z~ 6 quasars from Pan-STARRS1 

      Bañados, E.; Venemans, B. P.; Morganson, E.; Decarli, R.; Walter, F.; Chambers, K. C.; Rix, H.-W.; Farina, E. P.; Fan, X.; Jiang, L.; McGreer, I.; De Rosa, G.; Simcoe, R.; Weiß, A.; Price, P. A.; Morgan, J. S.; Burgett, W. S.; Greiner, J.; Kaiser, N.; Kudritzki, R.-P.; Magnier, E. A.; Metcalfe, N.; Stubbs, Christopher William; Sweeney, W.; Tonry, J. L.; Wainscoat, R. J.; Waters, C. (IOP Publishing, 2014)
      High-redshift quasars are currently the only probes of the growth of supermassive black holes and potential tracers of structure evolution at early cosmic time. Here we present our candidate selection criteria from the ...
    • Discovery of Giant Gamma-ray Bubbles in the Milky Way 

      Su, Meng (2012-08-09)
      Based on data from the Fermi Gamma-ray Space Telescope, we have discovered two gigantic gamma-ray emitting bubble structures in our Milky Way (known as the Fermi bubbles), extending \(\sim 50\) degrees above and below the ...
    • The Discovery of H2O Maser Emission in Seven AGN and at High Velocities in the Circinus Galaxy 

      Greenhill, Lincoln Jared; Kondratko, P. T.; Lovell, J. E. J.; Kuiper, T. B. H.; Moran, James M.; Jauncey, D. L.; Baines, G. P. (IOP Publishing, 2002)
      We report the discovery of H2O maser emission at 1.35 cm wavelength in seven active galactic nuclei (at distances up to < 80 Mpc) during a survey conducted at the 70-m diameter antenna of the NASA Deep Space Network near ...
    • Discovery of highly selective inhibitors to probe the physiology of the bacterial cell envelope 

      Muscato, Jacob (2022-05-11)
      Traditional high-throughput screening approaches have failed to efficiently discover specific, biologically active inhibitors for use as probes and development into therapeutics. New strategies are therefore required to ...
    • Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue 

      Ma, Jiao; Ward, Carl C.; Jungreis, Irwin; Slavoff, Sarah A.; Schwaid, Adam G.; Neveu, John; Budnik, Bogdan A.; Kellis, Manolis; Saghatelian, Alan (American Chemical Society, 2014)
      The existence of nonannotated protein-coding human short open reading frames (sORFs) has been revealed through the direct detection of their sORF-encoded polypeptide (SEP) products. The discovery of novel SEPs increases ...
    • Discovery of near-ultraviolet counterparts to millisecond pulsars in the globular cluster 47 Tucanae 

      Rivera-Sandoval, L. E.; van den Berg, Maureen C.; Heinke, C. O.; Cohn, H. N.; Lugger, P. M.; Freire, P.; Anderson, J.; Serenelli, A. M.; Althaus, L. G.; Cool, A. M.; Grindlay, Jonathan E.; Edmonds, P. D.; Wijnands, R.; Ivanova, N. (Oxford University Press (OUP), 2015)
      We report the discovery of the likely white dwarf companions to radio millisecond pulsars 47 Tuc Q and 47 Tuc S in the globular cluster 47 Tucanae. These blue stars were found in near-ultraviolet images from the Hubble ...
    • Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome 

      Homan, Edwin (2013-02-19)
      The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ...
    • Discovery of Novel Molecular Glues and Targeted Protein Degradation Mechanisms for Cancer Therapeutics 

      Li, Yen-Der (2023-05-03)
      Targeted protein degradation has emerged as a promising therapeutic approach that recruits cellular degradation machineries to induce degradation of target proteins. However, the mechanisms underlying many small molecule ...