Browsing Faculty of Arts and Sciences by FAS Department "Biological Sciences in Public Health"
Now showing items 1-20 of 48
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A Tale of Brothers, Sisters, Aunts and Uncles: Using Genomics and Modeling to Uncover the Nature of P. Falciparum Polygenomic Infections and Cotransmission
(2018-01-17)A curious feature of malaria epidemiology is the presence of polygenomic (multiple strain) infections in natural parasite populations. Polygenomic infections are an important aspect of malaria transmission and a necessary ... -
Alterations in Energy Metabolism and Neurodegeneration as a Conseqeunce of DNA Damage
(2017-01-18)The correlation between DNA damage and aging has been discussed since Peter Medawar framed the first modern theory of aging in 1952. In support of a causal relationship between DNA damage and aging, most human segmental ... -
ATF4 in the Control of Liver Metabolism Downstream of Anabolic and Stress Signals
(2020-01-22)The liver is a highly biosynthetic organ that mediates systemic metabolic flexibility by altering key metabolic pathways to match the dynamic fluctuations in nutrients that occur with fasting and feeding cycles. Despite ... -
Beyond Mutation: Epigenetic Drivers of Phenotypic Diversity and Survival in Mycobacteria
(2016-05-19)M. tuberculosis is the causative agent of a global health epidemic that kills ~1.5 million people each year. The outcomes of infection with Mtb are highly variable. Although many patients are able to control the infection ... -
Cell Non-Autonomous Modulation of Longevity by TORC1 and AMPK
(2018-04-20)Human life expectancy has increased dramatically over the last century. With more people living into older age, age-related chronic diseases have become a prominent challenge for biomedical research. AMP-activated protein ... -
Characterizing the Role of Pre-Pubertal Status in Sepsis: Why Do Children Survive When Adults Do Not
(2017-05-09)Epidemiological data from both historical and contemporary sources suggest that pre-pubertal children possess a relative resistance to death from severe infections and sepsis. To assess the role that pubertal status may ... -
Clp-Mediated Regulation of the Mycobacterial Cell Cycle
(2017-04-12)Tuberculosis is currently the most deadly infectious disease worldwide. Given the high rates of treatment failure, new antibiotics are desperately needed. Antibacterial drugs typically target DNA replication, cell growth, ... -
Control of HIV-1C Replication Both in Vivo and in Vitro
(2015-05-18)In this study, we established an HIV latency model using pluripotent stem cells in vitro. We found that a HIV accessory protein nef is responsible for full-length HIV silencing in human pluripotent stem cells. This effect ... -
CRISPR-based innovative genetic tools for control of Anopheles gambiae mosquitoes
(2019-05-14)Malaria and other mosquito-borne diseases pose an immense burden on mankind. Since the turn of the century, control campaigns have relied on the use of insecticide-impregnated bed nets and indoor residual sprays to stop ... -
Dietary unsaturated fat improves high density lipoprotein function: opposing roles of apoE and apoCIII
(2018-04-24)Cardiovascular disease is the leading cause of death worldwide. Atherosclerosis, the buildup of cholesterol-rich plaques in the arteries, is the pathophysiological process behind cardiovascular disease mortality. High ... -
Discovery of Small RNAs and Characterization of Their Regulatory Roles in Mycobacterium Tuberculosis
(2018-05-10)Mycobacterium tuberculosis is an important global health pathogen and is the leading cause of death due to an infectious disease. The pathogen resides inside of human macrophages and is exposed to a wide array of different ... -
Empowering the Experimental Biology of Plasmodium Vivax Through Elucidating Requirements for Ex Vivo Culture
(2019-05-06)For over 100 years, various research groups have been attempting to establish a continuous and robust in vitro culture system for the blood stages of various Plasmodium species, apicomplexan parasites that cause malaria, ... -
Epidemiology and Immunopathogenesis of Ebola and Flaviviruses
(2018-05-09)The spillover of emerging viruses into human populations continuously threatens public health. From 2013-2016, Ebola virus (EBOV) caused an explosive outbreak in West Africa with more than 28,000 cases, 11,000 of which ... -
Free Actin and Effects on Lung Macrophage Bacterial Defenses
(2017-02-10)Actin release into the circulation and extracellular space, with subsequent removal by the actin scavenging protein plasma gelsolin (pGSN), has long been reported in injury and infection. Our laboratory’s recent finding ... -
Friends of the Ribosome: Translational Regulation in Mycobacteria
(2019-05-14)Mycobacteria are responsible for a significant disease burden in the world, caused by Mycobacterium tuberculosis (Mtb) and non-tuberculous mycobacteria (NTM). While curable with a number of well-established antibiotic ... -
From Neural Stem Cells to Children: Secreted Phosphoprotein 1 in Lead Neurotoxicity
(2015-05-14)Lead (Pb) exposure in the earliest stages of neurodevelopment leads to lasting deficits in cognitive function and behavior. Neural stem cells (NSCs) are multipotent stem cells and the first cells of the central nervous ... -
Functional Analysis of Drug Resistance Associated Genetic Variation in Mycobacterium tuberculosis
(2020-04-17)Tuberculosis (TB) disease, caused by Mycobacterium tuberculosis (Mtb) infection, affects millions of people across the world annually. The best tool for controlling TB in individual patients and preventing transmission in ... -
Gametocyte-specific immunity provides a rationale for novel transmission blocking interventions in Plasmodium falciparum
(2017-05-04)The recent decline in global malaria burden has stimulated a renewed interest in malaria elimination and eradication. Understanding the biology of malaria transmission and identifying opportunities to interfere with the ... -
Growth factor signaling pathways converge on the TSC complex to control mTOR
(2019-05-16)The mechanistic target of rapamycin complex 1 (mTORC1) serves as a molecular link between cellular growth conditions and anabolic processes that are fundamental to cell growth and proliferation. However, while it is ... -
Gut and Tissue Microbiome Biogeography and Its Response to Environmental Perturbation
(2018-01-18)The symbiotic relationship between the host and its microbiome, which is composed of trillions of bacteria, archaea, viruses, and fungi, is essential for the host to maintain health. In the past two decades, the intestinal ...