Browsing Faculty of Arts and Sciences by Keyword "Cell Death"

Now showing items 1-7 of 7

    • Cationic Peptide Exposure Enhances Pulsed-Electric-Field-Mediated Membrane Disruption 

      Kennedy, Stephen M.; Aiken, Erik J.; Beres, Kaytlyn A.; Hahn, Adam R.; Kamin, Samantha J.; Hagness, Susan C.; Booske, John H.; Murphy, William L. (Public Library of Science, 2014)
      Background: The use of pulsed electric fields (PEFs) to irreversibly electroporate cells is a promising approach for destroying undesirable cells. This approach may gain enhanced applicability if the intensity of the PEF ...

    • Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio) 

      Uribe, Phillip M.; Mueller, Melissa; Gleichman, Julia S.; Kramer, Matthew; Wang, Qi; Sibrian-Vazquez, Martha; Strongin, Robert M.; Steyger, Peter S.; Cotanche, Douglas; Matsui, Jonathan I. (Public Library of Science, 2013)
      Inner ear sensory hair cells die following exposure to aminoglycoside antibiotics or chemotherapeutics like cisplatin, leading to permanent auditory and/or balance deficits in humans. Zebrafish (Danio rerio) are used to ...

    • Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration 

      Neel, Dylan Vijith (2023-09-06)
      Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) ...

    • Mechanistic Insights into the Conformational Regulation of Pro-Apoptotic BAX 

      Bloch, Noah Benjamin (2022-03-17)
      BCL-2 family proteins are apoptotic regulators that control the critical balance between cellular life and death at the level of the mitochondrion. BAX is a principal executioner of apoptosis, transforming from a latent ...

    • Phenotypic Heterogeneity and the Evolution of Bacterial Life Cycles 

      van Gestel, Jordi; Nowak, Martin A. (Public Library of Science, 2016)
      Most bacteria live in colonies, where they often express different cell types. The ecological significance of these cell types and their evolutionary origin are often unknown. Here, we study the evolution of cell differentiation ...

    • Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development 

      Perdigoto, Carolina N.; Dauber, Katherine L.; Bar, Carmit; Tsai, Pai-Chi; Valdes, Victor J.; Cohen, Idan; Santoriello, Francis J.; Zhao, Dejian; Zheng, Deyou; Hsu, Ya-Chieh; Ezhkova, Elena (Public Library of Science, 2016)
      An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes. Here, we have uncovered ...

    • Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution 

      Bozic, Ivana; Gerold, Jeffrey M.; Nowak, Martin A. (Public Library of Science, 2016)
      The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the reproductive rate of the cell. Passengers can provide important information about the evolutionary history of an individual ...