Browsing Faculty of Arts and Sciences by Keyword "High-throughput screening"
Now showing items 1-4 of 4
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Development of CoraFluors: A Versatile, Target-agnostic Assay Technology Platform Optimized for Chemical Biology Research
(2022-11-23)Biology uses strategic, coordinated proximity events to orchestrate complex cellular pathways essential to homeostasis, survival, and propagation. The interrogation of biological systems with chemogenomic approaches has ... -
Integrative approaches to expand the utility of CRISPR tiling mutagenesis screens for biological discovery
(2022-10-17)The development of CRISPR–Cas genome editing technologies has transformed our ability to perform complex genetic manipulations in situ. Furthermore, the programmable nature of CRISPR–Cas systems has enabled these manipulations ... -
Modulators of Cellular and Biochemical PRC2 Activity
(2014-10-21)EZH2 is a SET domain-containing methyltransferase and the catalytic component of the multimeric Polycomb- group (PcG) protein complex, PRC2. When in complex with other PRC2 members (EED, SUZ12, AEBP2, and RBBP4), EZH2 ... -
Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis
(BioMed Central, 2014)Background: RNA interference (RNAi) is an effective and important tool used to study gene function. For large-scale screens, RNAi is used to systematically down-regulate genes of interest and analyze their roles in a ...