Browsing Faculty of Arts and Sciences by Keyword "T cells"

Now showing items 1-9 of 9

    • BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes 

      Cooper, Zachary A; Frederick, Dennie T; Juneja, Vikram R; Sullivan, Ryan J; Lawrence, Donald P; Piris, Adriano; Sharpe, Arlene H; Fisher, David E; Flaherty, Keith T; Wargo, Jennifer A (Landes Bioscience, 2013)
      There have been significant advances with regard to BRAF-targeted therapies against metastatic melanoma. However, the majority of patients receiving BRAF inhibitors (BRAFi) manifest disease progression within a year. We ...

    • Cellular and Genetic Dynamics of the Melanoma Microenvironment 

      Stirtz, Georgia Layne (2023-04-26)
      The tumor microenvironment is comprised of a diverse assemblage of cells. These populations dynamically interact with one another in varied ways that modify the individual cells and shape the overall trajectory of the ...

    • Environmental Barriers to T Cell Metabolism and Function 

      Notarangelo, Giulia (2022-03-17)
      Immunometabolism describes the interface between immune cell function and metabolism. This interplay is governed by both cell-intrinsic metabolic programs that shape immune cell function, as well as environmental metabolites ...

    • Foxp3 Interacts With c-Rel to Mediate NF-\(\kappa\)B Repression 

      Loizou, Louiza; Andersen, Kristian G; Betz, Alexander G. (Public Library of Science, 2011)
      Expression of the lineage-specific DNA-binding factor Foxp3 controls the development and function of naturally occurring regulatory T cells. Foxp3 has been shown to interact with a multitude of transcriptional regulators ...

    • Integration of multimodal single-cell data to characterize T cell phenotypes, gene regulation, and disease associations 

      Nathan, Aparna (2022-07-28)
      T cells are heterogeneous immune cells with a spectrum of functional phenotypes—cell states—critical to processes ranging from infection to autoimmunity. Traditionally, T cells have been partitioned into mutually exclusive ...

    • Materials to enable and enhance T-cell immunotherapies 

      Zhang, Kongyu (2021-11-16)
      Immunotherapies involving engineered T cells have shown remarkable clinical outcomes for the treatment of cancer, particularly hematological malignancies, such as leukemia and lymphoma. However, several barriers need to ...

    • PD-1 function on T cells in spontaneous and anti-PD-1-mediated autoimmunity 

      Collier, Jenna Lynn (2023-01-18)
      Immune-related adverse events (irAEs) are a potentially life-threatening complication of PD-1 cancer immunotherapy in patients. A deeper understanding of irAEs is essential to inform strategies to treat and monitor irAEs. ...

    • Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection 

      Adnan, Sama; Reeves, R. Keith; Gillis, Jacqueline; Wong, Fay E.; Yu, Yi; Camp, Jeremy V.; Li, Qingsheng; Connole, Michelle; Li, Yuan; Piatak, Michael; Lifson, Jeffrey D.; Li, Wenjun; Keele, Brandon F.; Kozlowski, Pamela A.; Desrosiers, Ronald C.; Haase, Ashley T.; Johnson, R. Paul (Public Library of Science, 2016)
      Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive ...

    • TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection 

      Jayaraman, Pushpa; Jacques, Miye K.; Zhu, Chen; Steblenko, Katherine M.; Stowell, Britni L.; Madi, Asaf; Anderson, Ana C.; Kuchroo, Vijay K.; Behar, Samuel M. (Public Library of Science, 2016)
      While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ...