Browsing Faculty of Arts and Sciences by Keyword "Ubiquitin"
Now showing items 1-5 of 5
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Defining the Landscape of the PARKIN- and PINK1-Dependent Ubiquitin-Modified Proteome in Response to Mitochondrial Dysfunction
(2013-09-26)Parkinson's disease (PD) is a progressive neurological disorder resulting from loss of dopaminergic neurons of the substantia nigra, in part due to mitochondrial dysfunction. The E3 ubiquitin ligase, PARKIN, and mitochondrial ... -
Dynamic regulation of histone lysine methylation via the ubiquitin-proteasome system.
(2013-10-18)Lysine methylation is an important post-translational modification found on histones that is added and removed by histone lysine methyltransferases and demethylases, respectively. Lysine methylation occurs in a specific ... -
Identification of the Cellular Proteins and Pathways Engaged by the Bovine Papillomavirus Type 1 E6 and E7 Proteins
(2013-10-15)Bovine papillomavirus type 1 (BPV1) induces fibropapillomas in cattle, and has long served as a useful model virus to study the molecular biology of the papillomaviruses. The cellular transforming activity of BPV1 maps to ... -
Small molecule inhibitors reveal novel functions of the APC/C through proteomic and chemical genetic screening
(2020-08-11)The Anaphase Promoting Complex/Cyclosome (APC/C) is a ~1.2 MDa ubiquitin ligase that controls the timing of the eukaryotic cell cycle by targeting key proteins for destruction by the 26S proteasome. During M-phase, the ... -
Ubiquitin Recognition by the Proteasome
(2014-10-21)Ubiquitin proteasome pathway is an important cellular pathway that affects the fate of almost all intracellular proteins. Misregulation of this pathway has been found to be associated with a broad range of human diseases, ...