Browsing Faculty of Arts and Sciences by Keyword "beta cells"

Now showing items 1-2 of 2

    • Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway 

      Blum, Barak; Roose, Adam N; Barrandon, Ornella; Maehr, René; Arvanites, Anthony C; Davidow, Lance S; Davis, Jeffrey C; Peterson, Quinn P; Rubin, Lee L; Melton, Douglas A (eLife Sciences Publications, Ltd, 2014)
      Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but ...

    • Small-Molecule Suppressors of Cytokine-Induced Beta-Cell Apoptosis 

      Chou, Danny Hung-Chieh (2013-01-02)
      Type-1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells in the pancreas. Beta-cell apoptosis involves a complex set of signaling cascades initiated by \(interleukin-1\beta (IL-1\beta)\), ...