Browsing Faculty of Arts and Sciences by Keyword "cancer biology"

Now showing items 1-2 of 2

    • Bridging interpretable AI methods to systems biology and medical informatics 

      Yuan, Bo (2023-01-19)
      Computational modeling of biomedical systems can be used to describe and make therapeutically useful predictions of system behaviors, such as identifying potential drug targets or early detection of high-risk patients for ...

    • A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain 

      Levinson, Nicholas M; Kuchment, Olga; Shen, Kui; Young, Matthew A.; Koldobskiy, Michael; Karplus, Martin; Cole, Philip A; Kuriyan, John (Public Library of Science, 2006)
      The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by ...