Browsing Faculty of Arts and Sciences by Keyword "cell fate"

Now showing items 1-4 of 4

    • Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis 

      Chastanet, A.; Vitkup, D.; Yuan, Guocheng; Norman, Thomas Maxwell; Liu, Jun; Losick, Richard M. (Proceedings of the National Academy of Sciences, 2010)
      A model system for investigating how developmental regulatory networks determine cell fate is spore formation in Bacillus subtilis. The master regulator for sporulation is Spo0A, which is activated by phosphorylation via ...

    • LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11 

      Muralidharan, Bhavana; Khatri, Zeba; Maheshwari, Upasana; Gupta, Ritika; Roy, Basabdatta; Pradhan, Saurabh J.; Karmodiya, Krishanpal; Padmanabhan, Hari; Shetty, Ashwin S.; Balaji, Chinthapalli; Kolthur-Seetharam, Ullas; Macklis, Jeffrey D.; Galande, Sanjeev; Tole, Shubha (Society for Neuroscience, 2017)
      In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with unique molecular identities. The regulatory changes that occur ...

    • The regulatory functions of TIRR in DNA repair and p53-mediated cell fate 

      Parnandi, Nishita (2021-05-12)
      The tumor suppressor protein, TP53BP1, is an important DNA double-strand break (DSB) repair protein that is extensively regulated by post-translational modifications and protein-protein interactions. Our lab and others ...

    • Uncovering regulators of cellular differentiation using single-cell sequencing 

      Kukreja, Kalki (2023-11-21)
      New technologies have paved the way for addressing previously unanswerable questions. With rapid advancements in single-cell sequencing techniques, it is now possible to measure tens of thousands of molecules in millions ...