Browsing Faculty of Arts and Sciences by Keyword "cytotoxicity"
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The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine
(eLife Sciences Publications, Ltd, 2016)Phenotypic screens allow the identification of small molecules with promising anticancer activity, but the difficulty in characterizing the mechanism of action of these compounds in human cells often undermines their value ... -
Improving Zinc Finger Nucleases - Strategies for Increasing Gene Editing Activities and Evaluating Off-Target Effects
(2012-08-23)Zinc finger nucleases (ZFNs) induce double-strand DNA breaks at specific recognition sites. ZFNs can dramatically increase the efficiency of incorporating desired insertions, deletions, or substitutions in living cells. ...