Browsing Faculty of Arts and Sciences by Keyword "developmental biology"
Now showing items 1-20 of 33
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All β Cells Contribute Equally to Islet Growth and Maintenance
(Public Library of Science, 2007)In healthy adult mice, the β cell population is not maintained by stem cells but instead by the replication of differentiated β cells. It is not known, however, whether all cells contribute equally to growth and maintenance, ... -
Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord
(Public Library of Science, 2012)During the development of the spinal cord, proliferative neural progenitors differentiate into postmitotic neurons with distinct fates. How cells switch from progenitor states to differentiated fates is poorly understood. ... -
The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing
(Public Library of Science, 2010)Background: We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and Purkinje neurons. The methylation status of ... -
A Careful Look at Binding Site Reorganization in the even-skipped Enhancers of Drosophila and Sepsids
(Public Library of Science, 2008) -
The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros
(Public Library of Science, 2007)Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly understood. ... -
Characterization of the In Vivo Function of Neuropilin1 during Development
(2013-02-20)Neuropilin1 (Npn1) is a transmembrane receptor that is critical for development of both the nervous and vascular systems. It is a ligand for both the chemorepulsive Semaphorin3s and for vascular endothelial growth factor ... -
Chemical Genetics of Hematopoietic Stem Cell Transplantation
(2012-09-18)Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. ... -
Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis
(Public Library of Science, 2008)Chromosome movements are a general feature of mid-prophase of meiosis. In budding yeast, meiotic chromosomes exhibit dynamic movements, led by nuclear envelope (NE)-associated telomeres, throughout the zygotene and pachytene ... -
Development of bipolar interneuron subtypes within the retinal space-time continuum
(2022-01-18)Development of the retina requires precise production of more than 100 neuronal subtypes. How does such diversity emerge during development at the perfect time and place to create functional circuitry? Recent molecular ... -
Diverse Roles of Cell Signaling during Early and Late Phases of Limb Development
(2013-02-06)The development of the vertebrate limb is a progressive process characterized by initial induction and patterning, concomitant growth and morphogenesis, and subsequent cell differentiation and tissue formation. Many of ... -
Early Cell Fate Determination in Zebrafish
(2013-02-08)ESC/iPSC-derive somatic cells may be ideal for treating disorders caused by cellular deficiency or dysfunction. To form a lineage-specific cell population, ESCs/iPSCs undergo a multi-step process that recapitulates embryonic ... -
Evidence for a Novel Multipotent Mammary Progenitor with Pregnancy-Specific Activity
(2012-12-20)The mouse mammary gland has emerged as a model system for studying processes involved in the development of epithelial tissues. Current evidence suggests the existence of a differentiation hierarchy in the mammary gland, ... -
Functional Analysis of Notch Signaling during Vertebrate Retinal Development
(2013-02-25)The process of cell fate determination, which establishes the vastly diverse set of neural cell types found in the central nervous system, remains poorly understood. During retinal development, multipotent retinal progenitor ... -
Functional Relationship between Merlin and the ERM Proteins
(2012-11-15)The ability to spatially restrict specific activities across the cell cortex functionally defines individual cells and tissues. This is achieved, in part, via the assembly of protein complexes that link the plasma membrane ... -
Genetic Approaches to Study Human Embryonic Stem Cell Self-Renewal and Survival
(2012-08-23)Embryonic stem (ES) cells can be maintained indefinitely in culture while retaining the ability to give rise to cellular derivatives from the three germ layers. These unique characteristics hold great promise for regenerative ... -
Genome-Wide Identification of Binding Sites Defines Distinct Functions for Caenorhabditis elegans PHA-4/FOXA in Development and Environmental Response
(Public Library of Science, 2010)Transcription factors are key components of regulatory networks that control development, as well as the response to environmental stimuli. We have established an experimental pipeline in Caenorhabditis elegans that permits ... -
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
(Public Library of Science, 2008)In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 ... -
Identification and Characterization of Genes Essential for Human Brain Development
(2012-10-18)The human brain is a network of ninety billion neurons that allows for many of the behavioral adaptations considered unique to our species. One-fifth of these neurons are layered in an epithelial sheet known as the cerebral ... -
Investigation of the Molecular and Cellular Basis of Patterning, Morphogenesis, and Tubule Interconnections during Mammalian Kidney Development
(2013-02-19)The formation of a continuous tubular network in the mammalian urinary system requires the interconnection of two epithelial populations with distinct cellular origins. The proximal component of the renal network is the ... -
Mechanistic Studies of Polycomb Group Proteins
(2012-12-20)Most cells within multicellular organisms contain the same genetic information, yet the appropriate tissue-specific expression of genes is required for the proper formation of adult tissues. Genes can either be “turned on” ...