Browsing Faculty of Arts and Sciences by Keyword "diabetes"

Now showing items 1-10 of 10

    • Characterization of Protein-Metabolite and Protein-Substrate Interactions of Disease Genes 

      McFedries, Amanda Kathryn (2014-06-06)
      Discovery of protein-metabolite and protein-substrate interactions that can specifically regulate genes involved in human biology is an important pursuit, as the study of such interactions can expand our understanding of ...

    • Diabetes regulates fructose absorption through thioredoxin-interacting protein 

      Dotimas, James R; Lee, Austin W; Schmider, Angela B; Carroll, Shannon H; Shah, Anu; Bilen, Julide; Elliott, Kayla R; Myers, Ronald B; Soberman, Roy J; Yoshioka, Jun; Lee, Richard T (eLife Sciences Publications, Ltd, 2016)
      Metabolic studies suggest that the absorptive capacity of the small intestine for fructose is limited, though the molecular mechanisms controlling this process remain unknown. Here we demonstrate that thioredoxin-interacting ...

    • Environmental Exposures and Diabetes Risk 

      Fiffer, Melissa (2022-06-06)
      With type 2 diabetes (T2D) reaching epidemic proportions globally and domestically, and mounting evidence for the role of environmental exposures in diabetes risk, the time is ripe for further epidemiologic investigation ...

    • Environmentally induced changes in the gut microbiome and their role in the metabolic syndrome 

      Wibowo, Marsha Christanvia (2022-06-06)
      Previous studies have shown that lifestyle affects the gut microbiome. For example, a diet low in fiber leads to progressive loss of gut microbiome diversity across generations in mice. Industrial populations have a higher ...

    • Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts 

      Park, Lara K; Maione, Anna G; Smith, Avi; Gerami-Naini, Behzad; Iyer, Lakshmanan K; Mooney, David J; Veves, Aristidis; Garlick, Jonathan A (Taylor & Francis, 2014)
      Diabetic foot ulcers (DFUs) are a serious complication of diabetes. Previous exposure to hyperglycemic conditions accelerates a decline in cellular function through metabolic memory despite normalization of glycemic control. ...

    • Interpreting Metabolomic Profiles using Unbiased Pathway Models 

      Hunter, Luke; Pare, Guillaume; Vasan, Ramachandran S.; Lewis, Gregory D; Wang, Thomas Jue-Fuu; Chasman, Daniel Ian; Gerszten, Robert Edgardo; Deo, Rahul Chandrakant; Roth, Frederick Phillip (Public Library of Science, 2010)
      Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...

    • A Paper-Based “Pop-up” Electrochemical Device for Analysis of Beta-Hydroxybutyrate 

      Wang, Chien-Chung; Hennek, Jonathan; Ainla, Alar; Kumar, Ashok Ashwin; Lan, Wen-Jie; Im, Judy S; Smith, Barbara S.; Zhao, Mengxia; Whitesides, George McClelland (American Chemical Society (ACS), 2016)
      This paper describes the design and fabrication of a “pop-up” electrochemical paper-based analytical device (pop-up-EPAD) to measure beta-hydroxybutyrate (BHB)—a key biomarker for diabetic ketoacidosis—using a commercial ...

    • Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway 

      Blum, Barak; Roose, Adam N; Barrandon, Ornella; Maehr, René; Arvanites, Anthony C; Davidow, Lance S; Davis, Jeffrey C; Peterson, Quinn P; Rubin, Lee L; Melton, Douglas A (eLife Sciences Publications, Ltd, 2014)
      Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but ...

    • SREBP: A Key Effector of mTORC1 Signaling in Metabolism and Cancer 

      Yecies, Jessica (2013-01-02)
      The mammalian target of rapamycin complex 1 (mTORC1), a master regulator of cell growth and proliferation, is aberrantly activated in cancer, genetic tumor syndromes and obesity. Much progress has been made to understand ...

    • Using Stem Cells to Study and Possibly Treat Type 1 Diabetes 

      Melton, Douglas A. (The Royal Society, 2011)
      Stem cells with the potential to form many different cell types are actively studied for their possible use in cell replacement therapies for several diseases. In addition, the differentiated derivatives of stem cells are ...