Browsing Faculty of Arts and Sciences by Keyword "diversity-oriented synthesis"
Now showing items 1-3 of 3
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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria
(AmericanChemical Society, 2011)Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis ... -
Small-Molecule Suppressors of Cytokine-Induced Beta-Cell Apoptosis
(2013-01-02)Type-1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells in the pancreas. Beta-cell apoptosis involves a complex set of signaling cascades initiated by \(interleukin-1\beta (IL-1\beta)\), ... -
Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery
(2012-12-19)In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, ...