Browsing Faculty of Arts and Sciences by Keyword "structural variation"

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    • Extensive Genetic Diversity and Substructuring Among Zebrafish Strains Revealed through Copy Number Variant Analysis 

      Brown, Kim; Dobrinski, Kimberly P.; Lee, Arthur S.; Gokcumen, Omer; Mills, Ryan; Shi, Xinghua; Chong, Wilson W. S.; Chen, Jin Yun Helen; Yoo, Paulo; David, Sthuthi; Peterson, Samuel M.; Raj, Towfique; Choy, Kwong Wai; Stranger, Barbara; Williamson, Robin E.; Zon, Leonard Ira; Freeman, Jennifer L.; Lee, Charles (Proceedings of the National Academy of Sciences, 2012)
      Copy number variants (CNVs) represent a substantial source of genomic variation in vertebrates and have been associated with numerous human diseases. Despite this, the extent of CNVs in the zebrafish, an important model ...

    • The Evolutionary Significance of Chromosomal Inversions in Deer Mice 

      Harringmeyer, Olivia S (2024-03-12)
      Understanding the genomic basis of organismal adaptation remains a central goal of evolutionary biology. Chromosomal inversions – large segments of DNA in reverse orientation – can be major players in natural diversity ...