Browsing Faculty of Arts and Sciences by Keyword "ubiquitin"
Now showing items 1-4 of 4
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Defining the Ubiquitin and E2-Enzyme Requirements for APC/C-Mediated Degradation of Cyclin B1
(2012-09-12)Post-translational modification of proteins with ubiquitin regulates many aspects of cell physiology, including protein degradation. A uniform polyubiquitin chain that is linked through Lys48 has been widely accepted as ... -
Mass Spectrometry-Based Proteomics Approaches to Define Enzyme-Substrate Relationships in the Ubiquitin Proteasome System
(2022-11-23)The ubiquitin proteasome system (UPS) is a major regulator of cellular protein abundance, degrading proteins that are tagged with a ubiquitin post-translational modification. Respectively, E3 ubiquitin ligases and ... -
NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1
(MDPI, 2013)The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive ... -
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
(2014)Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. ...