Browsing Faculty of Arts and Sciences by Keyword "zebrafish"

Now showing items 1-20 of 25

    • Adaptive Locomotor Behavior in Larval Zebrafish 

      Portugues, Ruben; Engert, Florian (Frontiers Media SA, 2011)
      In this study we report that larval zebrafish display adaptive locomotor output that can be driven by unexpected visual feedback. We develop a new assay that addresses visuomotor integration in restrained larval zebrafish. ...

    • Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling 

      Lin, Michelle I; Price, Emily N; Boatman, Sonja; Hagedorn, Elliott J; Trompouki, Eirini; Satishchandran, Sruthi; Carspecken, Charles W; Uong, Audrey; DiBiase, Anthony; Yang, Song; Canver, Matthew C; Dahlberg, Ann; Lu, Zhigang; Zhang, Cheng Cheng; Orkin, Stuart H; Bernstein, Irwin D; Aster, Jon C; White, Richard M; Zon, Leonard I (eLife Sciences Publications, Ltd, 2015)
      Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show ...

    • Caudal Transcription Factors in Hematopoietic Development 

      Paik, Elizabeth Jae-Eun (2013-02-12)
      During embryogenesis, hematopoietic cells arise from the lateral plate mesoderm (LPM) following gastrulation. The transcriptional program required for this LPM to blood switch is not fully understood. Previous work on a ...

    • Challenging zebrafish escape responses by increasing water viscosity 

      Danos, N.; Lauder, George V. (The Company of Biologists, 2012)
      Escape responses of fishes have long been studied as a model locomotor behavior in which hypothesized maximal or nearmaximal muscle power output is used to generate rapid body bending. In this paper we present the results ...

    • Chemical Genetics of Hematopoietic Stem Cell Transplantation 

      Li, Pulin (2012-09-18)
      Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. ...

    • Chromatin-Modifying Factors in Zebrafish Models of Rhabdomyosarcoma and Hematopoiesis 

      Albacker, Colleen Elizabeth (2012-12-20)
      Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses modifications on both the DNA and histones and is as important as the DNA sequence itself. Gene transcription, ...

    • Control of Turning Behaviors by Spinal Projection Neurons in the Larval Zebrafish 

      Huang, Kuo-Hua (2012-09-17)
      This thesis aims to examine how hindbrain spinal projection neurons (SPNs), namely RoV3, MiV1 and MiV2 control tail undulations during turning behaviors. I find that phototaxic turns differ from forward swims by an increased ...

    • Decision Making, Behavioral Development and Fine Motor Control In Larval Zebrafish 

      Krishnan, Kumaresh (2023-05-02)
      All organisms need to make decisions after processing sensory inputs. The drift-diffusion model accurately captures average responses observed in the optomotor response of larval zebrafish but fails to capture the structure ...

    • Epigenetic Regulation of Hematopoiesis in Zebrafish 

      Huang, Hsuan-Ting (2012-11-02)
      The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of ...

    • The function of the Heg-CCM pathway in zebrafish heart development 

      Rosen, Jonathan Novick (2013-10-08)
      The Heart of glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for heart development in zebrafish and mouse. In zebrafish, mutants for the Heg-CCM genes ccm1, ccm2, and heg exhibit an extreme dilation ...

    • The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain 

      Bianco, Isaac; Wilson, Stephen W. (The Royal Society, 2009)
      The dorsal diencephalon, or epithalamus, contains the bilaterally paired habenular nuclei and the pineal complex. The habenulae form part of the dorsal diencephalic conduction (DDC) system, a highly conserved pathway found ...

    • Mlck1a Is Expressed in Zebrafish Thrombocytes and Is an Essential Component of Thrombus Formation 

      Tournoij, E.; Weber, G. J.; Akkerman, J. W. N.; De Groot, P. G.; Zon, Leonard Ira; Moll, F. L.; Schulte-Merker, S. (Wiley-Blackwell, 2009)
      Background: We have used the advantages of the zebrafish model system to demonstrate which of the vertebrate Myosin Light Chain Kinase (MLCK) genes is expressed in thrombocytes and important for thrombus formation. Methods ...

    • Monitoring Neural Activity with Bioluminescence during Natural Behavior 

      Naumann, Eva Aimable; Kampff, Adam R.; Prober, David A.; Schier, Alexander F; Engert, Florian (Nature Publishing Group, 2010)
      Existing techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons. We used bioluminescence to non-invasively monitor the activity ...

    • Navigational strategies underlying phototaxis in larval zebrafish 

      Chen, Xiuye; Engert, Florian (Frontiers Media S.A., 2014)
      Understanding how the brain transforms sensory input into complex behavior is a fundamental question in systems neuroscience. Using larval zebrafish, we study the temporal component of phototaxis, which is defined as ...

    • Prey Capture Behavior Evoked by Simple Visual Stimuli in Larval Zebrafish 

      Bianco, Isaac; Kampff, Adam R.; Engert, Florian (Frontiers Media SA, 2011)
      Understanding how the nervous system recognizes salient stimuli in the environment and selects and executes the appropriate behavioral responses is a fundamental question in systems neuroscience. To facilitate the ...

    • Propagation and Interpretation of Nodal Signaling 

      Carte , Adam Nathaniel (2022-06-06)
      The Nodal signaling pathway is integral to the development of many animal phyla, plays a conserved role in patterning the germ layers of all vertebrates, and has been implicated in numerous cancers and developmental diseases. ...

    • Regulators of hemoglobin switching in zebrafish and human models 

      Ganis, Jared Jason (2014-06-06)
      Hemoglobin switching is a developmental process involving the dynamic transcriptional regulation of multiple globin genes. This molecular process involves multiple layer of complexity, and elucidating new mechanisms in ...

    • Response to Nodal morphogen gradient is determined by the kinetics of target gene induction 

      Dubrulle, Julien; Jordan, Benjamin M; Akhmetova, Laila; Farrell, Jeffrey A; Kim, Seok-Hyung; Solnica-Krezel, Lilianna; Schier, Alexander F (eLife Sciences Publications, Ltd, 2015)
      Morphogen gradients expose cells to different signal concentrations and induce target genes with different ranges of expression. To determine how the Nodal morphogen gradient induces distinct gene expression patterns during ...

    • Sensational Propellers: Novel Protein Functions in Cilia Assembly and Motility 

      Austin, Christina Anne (2013-09-18)
      Cilia and flagella are hair-like projections found on the surface of virtually every vertebrate cell. These microtubule-based organelles are historically known for their striking motility, a valuable tool for the manipulation ...

    • Specificity of the Horizontal Cell-PhotoreceptorConnections in the Zebrafish (Danio Rerio) Retina 

      Li, Yong; Matsui, Jonathan I.; Dowling, John E. (Wiley-Blackwell, 2009)
      Horizontal cells (HCs) are involved in establishing the center-surround receptive field organization of photoreceptor and bipolar cells. In many species, HCs respond differentially to colors and may play a role in color ...