Browsing Faculty of Arts and Sciences by Keyword "BAX"
Now showing items 1-3 of 3
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Covalent Inhibition of Pro-Apoptotic BAX
(2023-06-01)BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. In response to cellular stress, BAX transforms ... -
Direct Inhibition of the Conformational Activation of Pro-Apoptotic BAX by the BH4 Domain Helix of BCL-2
(2014-10-21)Programmed cell death by apoptosis is required for normal development and tissue homeostasis. Perturbations of the critical signaling pathways that regulate apoptosis drive a number of pathologic diseases; therefore, a ... -
Mechanistic Insights into the Conformational Regulation of Pro-Apoptotic BAX
(2022-03-17)BCL-2 family proteins are apoptotic regulators that control the critical balance between cellular life and death at the level of the mitochondrion. BAX is a principal executioner of apoptosis, transforming from a latent ...