Browsing Faculty of Arts and Sciences by Keyword "Cancer"
Now showing items 1-20 of 31
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A Noncanonical Role of MCL-1 in Cell Cycle Progression
(2022-06-06)Myeloid cell leukemia 1 (MCL-1) is an anti-apoptotic BCL-2 family protein implicated in the development, maintenance, and chemoresistance of human cancer. MCL-1 is one of the most frequently amplified genes across a broad ... -
Biosensor Platforms for Molecular Analyses of Circulating Cancer Biomarkers
(2013-10-15)Solid cancers often shed (sub)cellular materials into the circulation, such as circulating tumor cells and extracellular microvesicles. Mounting evidence supports that these circulating materials could serve as surrogate ... -
Chemical Probes and the Exploration of Bromodomains in Cancer Biology
(2014-06-06)The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate ... -
Development and Application of Lysate Microarray Technology for Quantitative Analysis of Human Disease
(2013-08-28)Reductionist biology has yielded tremendous insight into the basis of biochemistry and genetic disease. However, the remarkable failure of reductionist biology to explain complex problems, especially cancer, has led to the ... -
Development of Methods for Cancer Genome Analysis and Clinical Applications
(2022-06-06)Cancer, a disease with increasing morbidity and mortality, was responsible for almost 20 million new cases and 10 million deaths worldwide in 2020, becoming one of the most significant public health issues of our time. ... -
Discovery of cancer vulnerabilities in gene expression regulation pathway
(2023-12-11)Cancer is one of the leading causes of death and many researchers are working on combating cancer. Despite significant progress in cancer therapeutics, many cancers still lack targeted therapies and new ways to enhance the ... -
Dysregulation of mSWI/SNF (BAF) Complexes in Human Malignancy
(2021-11-16)Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit, ATP-dependent, chromatin-remodeling protein complexes that increase the accessibility of DNA to transcriptional machinery. BAF complex perturbations are found ... -
Epigenetic based therapeutic strategies to drive differentiation and death in KRAS mutant colorectal cancers
(2023-06-01)Colorectal cancer (CRC) is one of the leading causes cancer deaths worldwide, and advanced metastatic disease is still incurable. Mutations in the KRAS oncogene occur in 30-50% of all CRC and render the malignancy resistant ... -
Exploiting signaling signatures in triple-negative breast cancer to identify targetable vulnerabilities
(2023-05-02)Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease with the worst five-year survival rate of all breast cancer subtypes. The standard of care for TNBC is chemotherapy, but not all patients ... -
Exploring Cancer's Fractured Genomic Landscape: Searching for Cancer Drivers and Vulnerabilities in Somatic Copy Number Alterations
(2014-10-21)Somatic copy number alterations (SCNAs) are a class of alterations that lead to deviations from diploidy in developing and established tumors. A feature that distinguishes SCNAs from other alterations is their genomic ... -
From Probes to Therapeutics: Chemical Biology Studies of Anaplastic Lymphoma Kinase (ALK) and Cereblon
(2020-01-22)Although there is still discussion surrounding the exact definition of the field, chemical biology is generally described as the development and deployment of a chemical toolbox to manipulate biological systems. The two ... -
Fully Synthetic Trioxacarcins for Use in Antibody-Drug Conjugates
(2021-05-10)Dissertation advisor: Professor Andrew G. Myers Ethan L. Magno Fully Synthetic Trioxacarcins for Use in Antibody-Drug Conjugates Abstract Antibody-drug conjugates (ADCs) have emerged as an effective, targeted therapeutic ... -
Functional Contribution of PDGFRbeta+ Cells in Angiogenesis and Metastatic Breast Cancer
(2013-10-18)Tumor stroma is known to affect tumor growth and metastasis. Inhibiting PDGF signaling, with the goal of depleting PDGFRβ+ stromal cells, is a putative therapeutic approach in this context. PDGFRβ is widely ... -
Genetic Determinants and Evolutionary Trajectories of Chronic Lymphocytic Leukemia
(2020-11-23)Chronic lymphocytic leukemia (CLL), the most common adult B cell malignancy, is known to have a variable disease course and multiple modes of therapeutic resistance. Recent large-scale sequencing efforts have uncovered ... -
Genetics, Endogenous and Exogenous Exposures, and Human Cancer
(2022-06-06)Cancer is a complex disease influenced by inherited germline variations and acquired somatic mutations from a variety of endogenous and exogenous exposures. Over the past decades, cancer research has mainly focused on ... -
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis
(2016)Recent studies have detailed the genomic landscape of primary endometrial cancers, but their evolution into metastases has not been characterized. We performed whole-exome sequencing of 98 tumor biopsies including complex ... -
Glucose Metabolism in Cancer-Associated Fibroblasts
(2013-08-28)Under normal conditions, non-transformed cells rely on glycolysis followed by oxidative phosphorylation to generate ATPs. When oxygen is scarce or when cells are actively proliferating, cellular ATPs come mainly from ... -
Manipulating Somatic Cells to Remove Barriers in Induced Pluripotent Stem Cell Reprogramming
(2013-10-08)Development leads unidirectionally towards a more restricted cell fate that is usually stable. However, it has been proven that developmental systems are reversible by the success of animal cloning of a differentiated ... -
Mechanisms Governing Mesothelial Clearance by Ovarian Cancer Spheroids
(2013-10-08)Metastatic dissemination of ovarian tumors involves the invasion of multi-cellular tumor cell clusters into the mesothelial cell lining of organs in the peritoneal cavity. We developed an in vitro assay that models this ... -
microRNA-mediated response to pathophysiological stress in the intestine
(2023-01-06)microRNAs (miRNAs) are short, 22-nt non-coding RNAs that modulate gene expressions post-transcriptionally. miRNAs are predicted to potentially target hundreds of genes simultaneously, rendering them crucial regulatory hubs ...