Browsing Faculty of Arts and Sciences by Keyword "Coalescent"

Now showing items 1-2 of 2

    • Distortions in Genealogies due to Purifying Selection 

      Nicolaisen, Lauren Elisabeth (2014-06-06)
      As deleterious variants continually arise in a population, they tend to be purged via purifying selection, leading to distortions in the shapes of genealogies relative to neutral expectations. In recent years, a mounting ...

    • The Structure of Genealogies in the Presence of Purifying Selection: a "Fitness-Class Coalescent" 

      Walczak, Aleksandra M.; Nicolaisen, Lauren Elisabeth; Plotkin, Joshua B.; Desai, Michael M (Genetics Society of America, 2012)
      Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be common in nature, our understanding of ...