Browsing Faculty of Arts and Sciences by Keyword "Diabetes"
Now showing items 1-5 of 5
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Cellular and Systemic Metabolic Adaptations to Energy Status
(2014-06-06)My thesis work has focused on physiological adaptations to nutrient stress; from genes, environment and hormonal perspective, and how failure of these systems result in common chronic diseases. -
Leveraging Geographic Information for Causal Inference in Pharmacoepidemiology
(2023-05-11)Randomized trials (RCT) with major adverse cardiovascular event (MACE) outcomes found no effect of dipeptidyl-peptidase-4 inhibitors (DPP-4i) medications compared to placebo or second-generation sulfonylureas (SU) while ... -
Manipulating the Gut Microbiome to Improve Health
(2021-09-09)The human gut microbiome is rapidly gaining attention for its connections to a long list of health and disease states, presenting new opportunities to modulate human health using microbiome therapeutics. In this dissertation, ... -
Modeling glucose dynamics during physical activity using a linear model for individuals with Type 1 Diabetes
(2023-06-30)For individuals with type 1 diabetes (T1D), regular exercise is beneficial as it can improve glycemic control, increase insulin sensitivity, improve body composition, and overall increase quality of life. However, physical ... -
Phenotypic High-Throughput Screening to Identify Small-Molecule Inhibitors of Beta-Cell Glucolipotoxicity
(2022-06-06)The global type 2 diabetes (T2D) epidemic continues to grow and by 2045, it is estimated 780 million adults will live with the disease. T2D is characterized by progressive pancreatic b-cell failure and loss of b-cell mass ...