Browsing Faculty of Arts and Sciences by Keyword "EGFR"
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Biochemical characterization of EGFR exon 20 insertion variants and their inhibitor sensitivities
(2023-04-26)Somatic mutations in the epidermal growth factor receptor (EGFR) are a major cause of non-small cell lung cancer (NSCLC). Among these structurally diverse alterations, exon 20 insertions represent a unique subset that ... -
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumors to TopoII inhibitors
(2014)SUMMARY Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide1. Chemotherapies such as the topoisomerase II inhibitor (TopoIIi) etoposide effectively reduce disease in a minority of NSCLC ...