Browsing Faculty of Arts and Sciences by Keyword "Epigenomics"
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Integrative approaches to expand the utility of CRISPR tiling mutagenesis screens for biological discovery
(2022-10-17)The development of CRISPR–Cas genome editing technologies has transformed our ability to perform complex genetic manipulations in situ. Furthermore, the programmable nature of CRISPR–Cas systems has enabled these manipulations ... -
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells
(Public Library of Science, 2014)Genome-wide association studies (GWAS) and subsequent dense-genotyping of associated loci identified over a hundred single-nucleotide polymorphism (SNP) variants associated with the risk of rheumatoid arthritis (RA), type ...