Browsing Faculty of Arts and Sciences by Keyword "brain"

Now showing items 1-9 of 9

    • Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation 

      Neelamegam, Ramesh; Ricq, Emily Louise; Malvaez, Melissa; Patnaik, Debasis; Norton, Stephanie; Carlin, Stephen M.; Hill, Ian Thomas; Wood, Marcelo A.; Haggarty, Stephen John; Hooker, Jacob M (American Chemical Society (ACS), 2012)
      Modulation of histone modifications in the brain may represent a new mechanism for brain disorder therapy. Post-translational modifications of histones regulate gene expression, affecting major cellular processes such as ...

    • Design, Synthesis, and Evaluation of Hydroxamic Acid-Based Molecular Probes for In Vivo Imaging of Histone Deacetylase (HDAC) in Brain 

      Hooker, Jacob M; Wang, Changning; Eessalu, Thomas E.; Barth, Vanessa N.; Mitch, Charles H.; Wagner, Florence F.; Hong, Yijia; Neelamegam, Ramesh; Schroeder, Frederick A; Holson, Edward B.; Haggarty, Stephen John (e-Century Publishing, 2014)
      Hydroxamic acid-based histone deacetylase inhibitors (HDACis) are a class of molecules with therapeutic potential currently reflected in the use of suberoylanilide hydroxamic acid (SAHA; Vorinostat) to treat cutaneous ...

    • For the Law, Neuroscience Changes Nothing and Everything 

      Greene, Joshua; Cohen, Jonathan D. (The Royal Society, 2004)
      The rapidly growing field of cognitive neuroscience holds the promise of explaining the operations of the mind in terms of the physical operations of the brain. Some suggest that our emerging understanding of the physical ...

    • Large-Scale Networks in the Human Brain revealed by Functional Connectivity MRI 

      Krienen, Fenna Marie (2013-10-18)
      The human brain is composed of distributed networks that connect a disproportionately large neocortex to the brainstem, cerebellum and other subcortical structures. New methods for analyzing non-invasive imaging data have ...

    • Memory: sins and virtues 

      Schacter, Daniel L. (Wiley-Blackwell, 2013)
      Memory plays an important role in everyday life but does not provide an exact and unchanging record of experience: research has documented that memory is a constructive process that is subject to a variety of errors and ...

    • Molecular and Bioinformatic Analysis of Neurotropic HIV Envelope Glycoproteins 

      Mefford, Megan (2012-08-15)
      Human immunodeficiency virus (HIV) infection of macrophages in brain and other tissues plays an important role in development of HIV-associated neurological disorders and other aspects of disease pathogenesis. Macrophages ...

    • Radiosynthesis and Evaluation of [11C]EMPA as a Potential PET Tracer for Orexin 2 Receptors 

      Wang, Changning; Moseley, Christian K.; Carlin, Stephen M.; Wilson, Colin M.; Neelamegam, Ramesh; Hooker, Jacob M (Elsevier BV, 2013)
      EMPA is a selective antagonist of orexin 2 (OX2) receptors. Previous literature with [3H]-EMPA suggest that it may be used as an imaging agent for OX2 receptors; however, brain penetration is known to be modest. To evaluate ...

    • The role of Ppargc1álpha in neuronal survival and myelination in the neocortex 

      Lin, Youshan Melissa (2014-02-25)
      The mammalian neocortex contains diverse neuronal and glial cell types. Among them lies an important subclass, the subcerebral projection neurons (SCPN) that project to distant targets like the spinal cord. Aiming at ...

    • The Nature and Origins of Selectivity for Music in the Human Brain 

      Boebinger, Dana (2022-01-04)
      Music is uniquely and universally human, and arises early in development. Recent fMRI studies have revealed neural populations in non-primary auditory cortex that respond selectively to music, responding strongly to a wide ...