Now showing items 1-6 of 6

    • Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase UCHL3 

      Artavanis-Tsakonas, Katerina; Weihofen, Wilhelm Andreas; Antos, John M.; Coleman, Bradley Ian; Comeaux, Christy Ann; Duraisingh, Manoj T.; Gaudet, Rachelle; Ploegh, Hidde L. (American Society for Biochemistry and Molecular Biology, 2010)
      Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. We previously identified PfUCHL3, a deubiquitinating enzyme, and here we characterize its activity and changes ...
    • Crystal Structure of Neocarzinostatin, an Antitumor Protein-Chromophore Complex 

      Kim, Kyoung-Hee; Kwon, Byoung-Mog; Myers, Andrew; Rees, Douglas (American Association for the Advancement of Science, 1993)
      Structures of the protein-chromophore complex and the apoprotein form of neocarzinostatin were determined at 1.8 angstrom resolution. Neocarzinostatin is composed of a labile chromophore with DNA-cleaving activity and a ...
    • Molecular basis of ion permeability in a voltage‐gated sodium channel 

      Naylor, Claire E; Bagnéris, Claire; DeCaen, Paul G; Sula, Altin; Scaglione, Antonella; Clapham, David E; Wallace, BA (John Wiley and Sons Inc., 2016)
      Abstract Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events ...
    • Molecular basis of sidekick-mediated cell-cell adhesion and specificity 

      Goodman, Kerry M; Yamagata, Masahito; Jin, Xiangshu; Mannepalli, Seetha; Katsamba, Phinikoula S; Ahlsén, Göran; Sergeeva, Alina P; Honig, Barry; Sanes, Joshua R; Shapiro, Lawrence (eLife Sciences Publications, Ltd, 2016)
      Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of retinal neurons. Sdks mediate cell-cell adhesion with homophilic ...
    • Ultrathin CVD Cu Seed Layer Formation Using Copper Oxynitride Deposition and Room Temperature Remote Hydrogen Plasma Reduction 

      Kim, Hoon; Bhandari, Harish B; Xu, Sheng; Gordon, Roy Gerald (Electrochemical Society, 2008)
      Cu seed layers for future interconnects must have conformal step coverage, smooth surface morphology, and strong adhesion. Conformal deposition had been achieved by chemical vapor deposition (CVD), but CVD Cu films have ...
    • X-Ray Grazing Incidence Diffraction from Alkylsiloxane Monolayers on Silicon Wafers 

      Tidswell, I. M.; Rabedeau, T. A.; Pershan, Peter S.; Kosowsky, S. D.; Folkers, J. P.; Whitesides, George M. (American Institute of Physics, 1991)
      X‐ray reflection (both specular and off‐specular) and grazing incidence diffraction (GID) have been used to study the structure of alkylsiloxane monolayers (\(n‐C_{18}H_{37}SiO_{1.5}\)) formed by self‐assembly from solution ...