Browsing Faculty of Arts and Sciences by Keyword "diversity-oriented synthesis"

Now showing items 1-3 of 3

    • Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria 

      Mulrooney, Carol; Austin, Christopher P.; Beaudoin, Jennifer A.; Cheng, Ken Chih-Chien; Comer, Eamon; Dandapani, Sivaraman; Dick, Justin; Duvall, Jeremy R.; Ekland, Eric H.; Fidock, David A.; Guha, Rajarshi; Hinkson, Paul; Kramer, Martin; Masi, Daniela; Marcaurelle, Lisa A.; Su, Xin-Zhuan; Weïwer, Michel; Xia, Menghang; Yuan, Jing; Zhao, Jinghua; Palmer, Michelle; Munoz, Benito; Heidebrecht, Richard W; Barker, Robert Howard; Fitzgerald, Mark E.; Foley, Michael Raymond; Lukens, Amanda Kathleen; Thomas, Craig J.; Wiegand, Roger C.; Wirth, Dyann Fergus; Schreiber, Stuart L. (AmericanChemical Society, 2011)
      Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis ...

    • Small-Molecule Suppressors of Cytokine-Induced Beta-Cell Apoptosis 

      Chou, Danny Hung-Chieh (2013-01-02)
      Type-1 diabetes is caused by the autoimmune destruction of insulin-producing beta cells in the pancreas. Beta-cell apoptosis involves a complex set of signaling cascades initiated by \(interleukin-1\beta (IL-1\beta)\), ...

    • Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery 

      Wang, Yikai (2012-12-19)
      In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, ...