Browsing Faculty of Arts and Sciences by Keyword "p53"
Now showing items 1-9 of 9
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Dynamics of p53 tetramers in live single cells
(2014-06-06)Protein homo-oligomerization is the process through which identical peptides bind together to form higher order complexes. Self-interactions in many cases are constitutive and stable, used as building blocks for biological ... -
The Facilitation of Protein-DNA Search and Recognition by Multiple Modes of Binding
(2012-12-12)The studies discussed in this thesis unify experimental and theoretical techniques, both established and novel, in investigating the problem of how a protein that binds specific sites on DNA translocates to, recognizes, ... -
Genome-Wide Loss-of-Function Genetic Screens Identify Novel Senescence Genes and Putative Tumor Suppressors
(2013-02-22)During every cell cycle and upon exogenous stress, tumor suppression programs are engaged to ensure genomic stability. In response to replicative aging and oncogenic stimuli, the p53 and Rb pathways are activated to prevent ... -
Identification of proteins binding coding and non-coding human RNAs using protein microarrays
(BioMed Central, 2012)Background: The regulation and function of mammalian RNAs has been increasingly appreciated to operate via RNA-protein interactions. With the recent discovery of thousands of novel human RNA molecules by high-throughput ... -
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
(BioMed Central, 2013)Background: The tumor suppressor protein p53 is activated by cellular stress. DNA double strand breaks (DSBs) induce the activation of the kinase ATM, which stabilizes p53 and activates its transcriptional activity. Single ... -
Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
(BioMed Central, 2013)Background: The p53 transcription factor is located at the core of a complex wiring of signaling pathways that are critical for the preservation of cellular homeostasis. Only recently it has become clear that p53 regulates ... -
Quantitative Analysis of DNA Repair and p53 in Individual Human Cells
(2013-03-18)The goal of my research was to obtain a quantitative understanding of the mechanisms of DNA double-strand break (DSB) repair, and the activation of the tumor suppressor p53 in response to DSBs in human cells. In Chapter ... -
Regulatory Interaction of the Class III PI3 Kinase Complex and p53
(2012-10-23)Autophagy is a catabolic pathway utilized by cells to maintain homeostasis. Dysregulation of this pathway often leads to various diseases, such as cancers and neurodegeneration. Therefore, autophagy must be tightly regulated ... -
The regulatory functions of TIRR in DNA repair and p53-mediated cell fate
(2021-05-12)The tumor suppressor protein, TP53BP1, is an important DNA double-strand break (DSB) repair protein that is extensively regulated by post-translational modifications and protein-protein interactions. Our lab and others ...