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An Engineered Calmodulin-Based Allosteric Switch for Peptide Biosensing
(Wiley Blackwell (John Wiley & Sons), 2013)
This work describes the development of a new platform for allosteric protein engineering that takes advantage of the ability of calmodulin to change conformation upon binding to peptide and protein ligands. The switch we ...
Progress Toward the Total Synthesis of Vinigrol and Hibarimicin B
(2014-02-25)
Vinigrol is a structurally unique diterpenoid natural product featuring a tricyclo[4.4.4.0.4a,8a]tetradecene carbon skeleton containing eight contiguous stereocenters and a challenging oxygenation pattern. Vinigrol has ...
Multi-Electron Reduction of Small Molecules by Triiron Reaction Sites
(2013-10-15)
The observation that multi-electron activation of small molecule substrates occurs at polynuclear reaction sites, common to both metalloenzymes and heterogeneous catalysts, has led to the articulation of the polynuclear ...
Design and synthesis of dynamically assembling DNA nanostructures
(2014-02-25)
Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed ...
I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides
(2014-02-25)
Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two ...
A Witness for Coherent Electronic vs Vibronic-Only Oscillations in Ultrafast Spectroscopy
(American Institute of Physics, 2012)
We report a conceptually straightforward witness that distinguishes coherent electronic oscillations from their vibronic-only counterparts in nonlinear optical spectra of molecular aggregates. Coherent oscillations as a ...
On the Alternatives for Bath Correlators and Spectral Densities from Mixed Quantum-Classical Simulations
(American Institute of Physics, 2012)
We investigate on the procedure of extracting a “spectral density” from mixed QM/MM calculations and employing it in open quantum systems models. In particular, we study the connection between the energy gap correlation ...
Trapping and Manipulating Single Molecules of DNA
(2014-02-25)
This thesis presents the development and application of nanoscale techniques to trap and
The Role of Catalyst-Catalyst Interactions in Asymmetric Catalysis with (salen)Co(III) Complexes and H-Bond Donors
(2013-10-14)
In asymmetric catalysis, interactions between multiple molecules of catalyst can be important for achieving high catalyst activity and stereoselectivity. In Chapter 1 of this thesis, we introduce catalyst-catalyst interactions ...
Paper-Based Analytical Device for Electrochemical Flow-Injection Analysis of Glucose in Urine
(American Chemical Society (ACS), 2012)
This article describes a new design for a paper-based electrochemical system for flow-injection analysis. Capillary wicking facilitates a gravity-driven flow of buffer solution continuously through paper and nitrocellulose, ...