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Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
(2017-07-06)
Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...
Katherine Cohen Senior Thesis
(2018-06-29)
The viral dynamics model based on a system of differential equations is an incredibly useful tool towards understanding the kinetics of HIV. The parameters of the system of equations provide important insights into the ...
Experimental and Computational Tools to Study P53 Dynamics at the Single-Cell Level
(2015-09-21)
One of the most commonly mutated genes found in cancer is the tumor suppressor p53. p53 is a transcription factor capable of inducing cell-cycle arrest, apoptosis, senescence, and other cellular processes thought to halt ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Regulation of Yolk Catabolism in Early Embryogenesis
(2015-08-19)
Yolk provides an important source of nutrients during the early development of oviparous (non-platental) organisms. In addition to phosphate and lipids, it is com- posed mainly of vitellogenin proteins packed into ...
Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia
(2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
PI3K regulatory subunit p85alpha plays a tumor suppressive role in the transformation of mammary epithelial cells
(2015-01-15)
Hyperactivation of the phosphatidylinositol 3-kinase (PI3K) pathway is one of the most common events in human cancers. Class IA PI3Ks are heterodimers of a p110 catalytic and a p85 regulatory subunit that coordinate the ...
Bioinformatic and molecular study of the regulation of SIRT3 expression
(2015-01-29)
Calorie restriction (CR) is a dietary intervention that extends lifespan, delays the onset of age-related diseases, and induces a wide-ranging metabolic adaptation in multiple model organisms. One of its primary effectors ...
The Mechanistic Basis of Dynein Microtubule Binding and Its Regulation
(2015-01-22)
Eukaryotic cells use a diverse toolbox of cytoskeletal motors to transport and position cellular materials in space and time. Two microtubule-based motors—kinesin and dynein—transport organelles, RNA and protein cargos ...
Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium
(2015-01-23)
Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...