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Breed Differences in Domestic Dogs' (Canis familiaris) Comprehension of Human Communicative Signals
(John Benjamins Publishing Company, 2009)
Recent research suggests that some human-like social skills evolved in dogs (Canis familiaris) during domestication as an incidental by-product of selection for “tame” forms of behavior. It is still possible, however, that ...
Stepwise Acquisition of Pyrimethamine Resistance in the Malaria Parasite
(National Academy of Sciences, 2009)
The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance ...
High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast
(Public Library of Science, 2006)
Understanding the genetic basis of evolutionary adaptation is limited by our ability to efficiently identify the genomic locations of adaptive mutations. Here we describe a method that can quickly and precisely map the ...
The Case for Selection at CCR5-Δ32
(Public Library of Science, 2005)
The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Δ32 arose within the past 1,000 y and rose to ...
The Cost of Gene Expression Underlies a Fitness Trade-Off in Yeast
(National Academy of Sciences, 2009)
Natural selection optimizes an organism's genotype within the context of its environment. Adaptations to one environment can decrease fitness in another, revealing evolutionary trade-offs. Here, we show that the cost of ...
Eukaryotic Organisms in Proterozoic Oceans
(Royal Society, The, 2006)
The geological record of protists begins well before the Ediacaran and Cambrian diversification of animals, but the antiquity of that history, its reliability as a chronicle of evolution and the causal inferences that can ...
Burkholderia Xenovorans LB400 Harbors a Multi-Replicon, 9.73-Mbp Genome Shaped for Versatility
(National Academy of Sciences, 2006)
<i>Burkholderia xenovorans</i> LB400 (LB400), a well studied, effective polychlorinated biphenyl-degrader, has one of the two largest known bacterial genomes and is the first nonpathogenic <i>Burkholderia</i> isolate ...
Recognizing and Interpreting the Fossils of Early Eukaryotes
(Springer Verlag, 2003)
Using molecular sequence data, biologists can generate hypotheses of protistan phylogeny and divergence times. Fossils, however, provide our only direct constraints on the timing and environmental context of early eukaryotic ...
Optimization of Gene Expression by Natural Selection
(National Academy of Sciences, 2009)
It is generally assumed that stabilizing selection promoting a phenotypic optimum acts to shape variation in quantitative traits across individuals and species. Although gene expression represents an intensively studied ...
Detective Work in the West Indies: Integrating Historical and Experimental Approaches to Study Island Lizard Evolution
(American Institute of Biological Sciences, 2007)
Evolutionary biology is a historical science, like astronomy and geology. Understanding how and why evolution has occurred requires synthesizing multiple lines of inquiry. Historical studies, such as those that estimate ...