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The effect of one additional driver mutation on tumor progression
(Blackwell Publishing Ltd, 2013)
Tumor growth is caused by the acquisition of driver mutations, which enhance the net reproductive rate of cells. Driver mutations may increase cell division, reduce cell death, or allow cells to overcome density-limiting ...
Prosperity is Associated with Instability in Dynamical Networks
(Elsevier, 2012)
Social, biological and economic networks grow and decline with occasional fragmentation and re-formation, often explained in terms of external perturbations. We show that these phenomena can be a direct consequence of ...
The Evolution of Homophily
(Nature Publishing Group, 2012)
Biologists have devoted much attention to assortative mating or homogamy, the tendency for sexual species to mate with similar others. In contrast, there has been little theoretical work on the broader phenomenon of ...
Antiretroviral dynamics determines HIV evolution and predicts therapy outcome
(Nature Publishing Group, 2012)
Despite the high inhibition of viral replication achieved by current anti-HIV drugs, many patients fail treatment, often with emergence of drug-resistant virus. Clinical observations show that the relationship between ...
The Evolution of Cell-to-Cell Communication in a Sporulating Bacterium
(Public Library of Science, 2012)
Traditionally microorganisms were considered to be autonomous organisms that could be studied in isolation. However, over the last decades cell-to-cell communication has been found to be ubiquitous. By secreting molecular ...
Selection for Replicases in Protocells
(Public Library of Science, 2013)
We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the ...
Cooperation and the Fate of Microbial Societies
(Public Library of Science, 2013)
Microorganisms have been cooperating with each other for billions of years: by sharing resources, communicating with each other, and joining together to form biofilms and other large structures. These cooperative behaviors ...
Evolution of In-Group Favoritism
(Nature Publishing Group, 2012)
In-group favoritism is a central aspect of human behavior. People often help members of their own group more than members of other groups. Here we propose a mathematical framework for the evolution of in-group favoritism ...
Infectious Disease Modeling of Social Contagion in Networks
(Public Library of Science, 2010)
Many behavioral phenomena have been found to spread interpersonally through social networks, in a manner similar to infectious diseases. An important difference between social contagion and traditional infectious diseases, ...
Imitation Dynamics of Vaccination Behaviour on Social Networks
(Royal Society of London, 2011)
The problem of achieving widespread immunity to infectious diseases by voluntary vaccination is often presented as a public-goods dilemma, as an individual's vaccination contributes to herd immunity, protecting those who ...