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The Effect of Development and Ecology on the Evolution of Ovary Size in Drosophila
(2015-05-20)
How the size of an organ is established and altered during evolution is poorly understood. The ovary of fruit flies of the genus Drosophila serves as an interesting model for understanding organ size evolution, as the ...
The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia
(2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
Oligopaints: Highly Programmable Oligonucleotide Probes for Visualizing Genomes in Situ
(2015-01-29)
Fluorescence in situ hybridization (FISH) is a powerful assay that can visualize the position of DNA and RNA molecules in individual cells. Here, I describe the development of a method that utilizes complex oligonucleotide ...
Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium
(2015-01-23)
Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...
In Vivo and in Vitro Characterization of the Tumor Suppressive Function of INPP4B
(2015-05-16)
The phosphatases PTEN and INPP4B are frequently deregulated in human cancer and have been proposed to act as tumor suppressor genes by coordinately antagonizing PI3K/AKT signaling. While the function of PTEN has been ...
Control of HIV-1C Replication Both in Vivo and in Vitro
(2015-05-18)
In this study, we established an HIV latency model using pluripotent stem cells in vitro. We found that a HIV accessory protein nef is responsible for full-length HIV silencing in human pluripotent stem cells. This effect ...
The Metabolic Role of the Hippo Pathway in Liver Development and Cancer
(2015-05-12)
Hepatocellular carcinoma (HCC) is a global health problem with poor prognosis and limited therapeutic options. While the clinical risk factors for HCC are well described, the precise molecular and metabolic mechanisms ...
Interrogation of the RP-MDM2-P53 Axis in Human Ribosomopathies
(2015-05-15)
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characterized by heterozygous loss or mutation of ribosome-associated genes. Hallmarks of these diseases include a macrocytic anemia ...