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Regulatory consequences of variation in transcription factor-DNA binding
(2022-03-17)
Transcription factors bind to their target DNA sites in a sequence-specific manner, modulating gene expression, and playing important roles in development, body patterning, cellular differentiation, and stimuli response. ...
Synthetic Genome Construction Techniques to Edit the Genetic Code of Escherichia coli
(2022-11-23)
The expansion of the genetic code to allow for site-specific incorporation of non-standard amino acids (nsAAs) — proteogenic amino acids other than the 22 found across life — is an important step in the development of new ...
Regulation of Cell Wall Hydrolysis by the WalRK Two-Component System in Bacillus subtilis
(2022-01-18)
The cell envelope surrounds the bacterial cell, providing physical integrity, mediating contact with the surrounding environment, and acting as a barrier against external assaults. The cell wall forms the structural ...
Identification and Interpretation of Causal Genetic Variants Underlying Human Phenotypes
(2022-05-16)
Human genetics provides a powerful approach for the identification of genetic loci involved in the pathogenesis of human disease. Whole exome (WES), and increasingly whole genome, sequencing have allowed for the identification ...
Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms
(2022-05-10)
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...
Characterization of transcription factor function during human gametogenesis via directed differentiation
(2022-06-06)
It is estimated that one in ten people in the US struggle with infertility. Access to human germline cell types for study is limited, and little is known about the underlying genetic regulation of human gametogenesis. In ...
High-throughput functional characterization of regulatory variants related to human evolution and disease
(2022-05-18)
Evolutionary genetics is at an exciting crossroads due to the growing ability to functionally characterize non-coding regions enabled by high-throughput genomic technologies. Although coding sequence differences between ...
Harnessing Advances in Genomics and Molecular Genetics to Inform Understanding of P. vivax Epidemiology, Evolution, and Drug Resistance
(2022-04-28)
Plasmodium vivax and Plasmodium falciparum are two parasites that cause most malaria cases worldwide. P. vivax is chronically understudied compared to P. falciparum, and significant aspects of its biology remain a mystery. ...
In situ epigenomics across length scales
(2022-09-09)
Chromatin is spatially organized across length scales, from DNA base pairs to chromosomes to tissues. This organization, which is encompassed in the term epigenomics, is thought to regulate gene expression and control ...
AGE REVERSAL BY TRANSCRIPTOMIC REPROGRAMMING
(2022-11-23)
Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as cancer, cardiovascular, and neurodegenerative diseases are leading causes of death worldwide. As the ...