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The role of RNA splicing factors in the regulation of longevity
(2021-11-16)
Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...
Transposable Elements in Health and Disease
(2021-11-16)
Transposable elements are DNA sequences that can move within the genome. They play a pivotal role in genomic variability in humans and can cause diseases. Their repetitive nature requires specific computational algorithms ...
Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms
(2022-05-10)
Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...
AGE REVERSAL BY TRANSCRIPTOMIC REPROGRAMMING
(2022-11-23)
Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as cancer, cardiovascular, and neurodegenerative diseases are leading causes of death worldwide. As the ...
Analyzing the multidimensionality of aging by using machine learning to predict age from diverse medical datasets
(2021-05-12)
The world population is aging, leading to a rise in the prevalence of age-related diseases such as cardiovascular disease and cancer. In parallel to treating the diseases, an attractive idea is to address the problem at ...
Enhanced Genomic Stability and its Effects on Aging and the Epigenome
(2022-01-18)
The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ...
The evolution of longevity in the context of epigenetic regulation and genetic sequence evolution
(2022-11-23)
Modern-day humans enjoy an elongated lifespan relative to chimpanzees, even when accounting for environmental factors such as healthcare. This suggests that genetic changes to the biological processes underlying longevity ...