Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...

Transposable elements are DNA sequences that can move within the genome. They play a pivotal role in genomic variability in humans and can cause diseases. Their repetitive nature requires specific computational algorithms ...

Biguanides, including the world’s most commonly prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these ...

Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as cancer, cardiovascular, and neurodegenerative diseases are leading causes of death worldwide. As the ...

The world population is aging, leading to a rise in the prevalence of age-related diseases such as cardiovascular disease and cancer. In parallel to treating the diseases, an attractive idea is to address the problem at ...

The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ...

Modern-day humans enjoy an elongated lifespan relative to chimpanzees, even when accounting for environmental factors such as healthcare. This suggests that genetic changes to the biological processes underlying longevity ...