Now showing items 1-6 of 6
Regulatory consequences of variation in transcription factor-DNA binding
Transcription factors bind to their target DNA sites in a sequence-specific manner, modulating gene expression, and playing important roles in development, body patterning, cellular differentiation, and stimuli response. ...
Uncovering the biology of chromatin regulators with drug resistance alleles
For millennia, small molecules have served as the backbone of humanity’s therapeutic arsenal. Often less well appreciated is the important role that small molecules have played in the discovery of new biological phenomena. ...
Developments of MERFISH for functional genomics and spatial epigenomics
The recent development of spatial omics methods, enables spatial profiling of transcriptome and 3D structure of genomes at a single-cell level. Expanding the repertoire of spatial omics tools, a spatial epigenomics method ...
Precision Editing of Nuclear and Mitochondrial Genomes
The ability to convert a target nucleotide sequence into any desired nucleotide sequence has been a longstanding goal in genome editing. RNA-guided CRISPR-Cas systems have transformed this field because genome editing ...
The role of histone modifications in regulating nuclear rigidity and fate plasticity
Histone modifications annotate genome function and respond to the environment by modulating gene regulation. They can locally tune the chromatin structure to control expression. In aggregate, they globally influence nuclear ...
Genetics of Antibiotic Synergy in Mycobacterium tuberculosis
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb), which has been around for millennia and continues to affect millions of people every year. Successful TB treatment requires ...