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poly(UG)-tailed RNAs and Transgenerational Epigenetic Inheritance in C. elegans
Small noncoding RNAs (small RNAs) such as Piwi-interacting RNAs (piRNAs), microRNA (miRNAs), and short-interfering RNAs (siRNAs) are important regulators of gene expression. Small RNAs are bound by Argonaute proteins and, ...
Uncovering the biology of chromatin regulators with drug resistance alleles
For millennia, small molecules have served as the backbone of humanity’s therapeutic arsenal. Often less well appreciated is the important role that small molecules have played in the discovery of new biological phenomena. ...
Enhanced Genomic Stability and its Effects on Aging and the Epigenome
The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ...
Identifying novel genetic drivers of melanoma initiation, metastasis, and drug resistance using zebrafish
Sun-exposed cutaneous melanoma has the highest genomic mutational burden of all tumor types. Progression towards metastasis is responsible for most melanoma-related mortality, yet no recurrent mutations specifically driving ...
The evolution of longevity in the context of epigenetic regulation and genetic sequence evolution
Modern-day humans enjoy an elongated lifespan relative to chimpanzees, even when accounting for environmental factors such as healthcare. This suggests that genetic changes to the biological processes underlying longevity ...
Dissecting the embryonic and extraembryonic requirements for DNA methylation in mice
DNA methylation is a remarkably dynamic repressive DNA modification that can be stably propagated over successive cell divisions and forms an essential layer of the epigenetic landscape that defines each cell. In the early ...