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Design and Assembly Considerations in the Engineering of Vascular Tissue
(2014-02-25)
Native vascular tissue functions are highly dependent on structural organization at the super-cellular, cellular, and sub-cellular spatial scales. We hypothesized that the structure-function relationship of vascular tissues ...
Antigen-specific immune modulation using an injectable biomaterial
(2014-06-06)
The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific ...
Developmentally-Inspired Engineering Of An Inductive Biomaterial for Odontogenesis
(2014-06-06)
Increasing demands for organ transplants and the depleting supply of available organs has heightened the need for alternatives to this growing problem. Tissue engineers strive to regenerate organs in the future; however ...
Mechanisms and Implications of Fracture in Cardiovascular Stents
(2014-06-06)
Cardiovascular stents are one of the most widely implanted medical devices, with over 1 million implanted each year in the United States alone. While stent failure modes of restenosis and thrombosis have been widely examined, ...
Investigating the effect of liposomal membrane fluidity and antibody lateral mobility on endothelial cell targeting
(2014-06-06)
Atherosclerosis is initiated by the adhesion of leukocytes to the endothelial surface of arteries followed by migration beneath the intima. Current therapies to combat atherosclerotic plaque, such as statins or antihypertensive ...
Design Considerations for Engineered Myocardium
(2014-06-06)
The fabrication of biomimetic heart muscle suitable for pharmaceutical compound evaluation and disease modeling is hindered by limitations in our understanding of how to guide and assess the maturity of engineered myocardium ...
Fast Surgical Simulation to Improve Mitral Valve Repair
(2014-06-06)
Mitral valve repair, the preferred method of treating mitral regurgitation, is a demanding surgical procedure consisting of the resection and approximation of valve tissue. Operating on an arrested heart, the clinician is ...
Enhanced Ultrasound Visualization for Procedure Guidance
(2014-06-06)
Intra-cardiac procedures often involve fast-moving anatomic structures with large spatial extent and high geometrical complexity. Real-time visualization of the moving structures and instrument-tissue contact is crucial ...
Endothelial Progenitor Cell Recruitment for Therapeutic Neovascularization using Alginate Hydrogels for VEGF and SDF Delivery
(2014-06-06)
Endothelial progenitor cells are potentially useful as a cell therapy for the treatment of ischemic cardiovascular diseases, but clinical outcomes have been limited likely because very few systemically delivered cells reach ...
Optical control of mammalian endogenous transcription and epigenetic states
(2014-06-06)
The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates ...