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Katherine Cohen Senior Thesis
(2018-06-29)
The viral dynamics model based on a system of differential equations is an incredibly useful tool towards understanding the kinetics of HIV. The parameters of the system of equations provide important insights into the ...
Targeting FGFR to Overcome EMT-Related Resistance to EGFR Inhibition in EGFR-Mutated Non-Small Cell Lung Cancer
(2018-01-19)
Acquired drug resistance to tyrosine kinase inhibitor (TKI) targeted therapies remains a major clinical challenge. In EGFR mutant non-small cell lung cancer (NSCLC), therapeutic failure of EGFR TKIs can result from both ...
Large-Scale Studies of the Protein Biochemistry Regulating Meiotic Exit and Fertilization
(2018-05-13)
Dynamic post-translational modifications are central to coordinating complex biological processes. This is especially evident after fertilization, where the modification or destruction of the egg’s existing proteins is ...
Investigating the Roles of IRF6 in Epithelial Maturation, Craniofacial Development, and Orofacial Cleft Pathogenesis
(2018-04-10)
Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...
Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
Glycomic regulation of human B cells
(2018-09-16)
All leukocytes are coated with a dense layer of carbohydrates called the glycocalyx. Initially believed to serve largely biophysical roles, the glycocalyx is increasingly recognized as a gatekeeper of leukocyte interactions ...
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)
In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ...
Msp1 Protects Organelles Through Quality Control of Excess Membrane Proteins
(2018-01-16)
Quality control (QC) of membrane proteins is a critical but ill-understood process where undesirable proteins are sequestered or eliminated to protect cellular homeostasis. A recently described membrane protein QC pathway ...
Skeletal Muscle Macrophages: Characterization and Regulation by Regulatory T Cells
(2018-01-12)
Skeletal muscle regeneration is a highly orchestrated process that relies heavily on the immune system. Efficient regeneration post-acute injury requires both F4/80+ macrophages (MFs) and CD4+Foxp3+ T regulatory (Treg) ...
Investigation of KRAS Dependency Bypass and Functional Characterization of All Possible KRAS Missense Variants
(2018-05-11)
The importance of oncogenic KRAS in human cancers have prompted intense efforts to target KRAS and its effectors. To anticipate the development of resistance to these strategies, we previously performed a genome-scale ...