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Discovery and Characterization of Novel smORF-Encoded Polypeptides (SEPs)
(2016-01-04)
Peptides and small proteins have essential physiological roles including metabolism (insulin), sleep (orexin), and stress (corticotropin-releasing hormone). Recent exploration of the human genome and proteome has revealed ...
Identifying targets for potentiators in S. aureus using chemical genetic approaches
(2016-09-29)
Staphylococcus aureus is a highly feared Gram-positive pathogen. The rise in antibiotic resistance has made S. aureus infections intractable. To find new ways to treat S. aureus infections, it is important to understand ...
Type 2 Diabetes-Associated Variants Disrupt Function of SLC16A11
(2017-04-20)
Type 2 Diabetes (T2D) affects individuals of Mexican and Latin American descent at twice the rate seen in populations of European descent. Recently a risk haplotype in SLC16A11 that explains ~20% of the increased T2D ...
A Framework for Protein-Level Interpretation of Genetic Associations and Integration With Large-Scale DNA Sequencing Analysis
(2017-05-10)
With recent rapid decrease in exome and genome sequencing price amount of the available sequencing data has dramatically increased. While analysis of common genetic variation has succeeded with GWAS and fine-mapping ...