Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast tumors are classified based on the ...

Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...

Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...

Studies of complex multicellular organisms would benefit from the ability to selectively manipulate the activities of any cell type of interest. Our ability to achieve this is currently limited by technology and available ...

Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...

The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...

Despite nearly complete understanding of the genetics of the β-hemoglobinopathies for several decades, definitive treatment options have lagged behind. Fetal hemoglobin (HbF) reinduction represents a “silver bullet” for ...

Chromatin plays a vital role in the implementation of gene expression programs. Several disparate groups of regulatory proteins alter chromatin state through post-translational modification of histone proteins, nucleosome ...

Nodal signaling is one of the principal players in the process of gastrulation, during which the primary germ layers (endoderm, mesoderm, and ectoderm) are formed and organized in their proper locations. During my PhD I ...

Animals switch between periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. C. elegans exhibit periods of behavioral quiescence during larval molts (termed lethargus) ...