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Transcriptional Controls Over Specification of Neocortical Projection Neuron Subtype and Area Identity
(2015-08-04)
The complex and sophisticated neocortical circuits that mediate higher-order brain functions are assembled from an extraordinary variety of neuronal subtypes, each with distinct morphologies, output connectivity, and ...
Co-opting Intracellular Proteins for Cell-Specific Gene Manipulation
(2015-01-22)
Studies of complex multicellular organisms would benefit from the ability to selectively manipulate the activities of any cell type of interest. Our ability to achieve this is currently limited by technology and available ...
Characterization of Dopamine-Responsive Serotonergic Neurons Underlying Aggression Modulation
(2016-04-04)
The monoaminergic neuromodulatory systems (including the noraderenergic, serotonergic, and dopaminergic neuronal systems) have long been thought of as the custodians of mental health. Dysfunction amongst these neural ...
Regulation of Behavioral Arousal and Quiescence in C. elegans
(2016-05-13)
Animals switch between periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. C. elegans exhibit periods of behavioral quiescence during larval molts (termed lethargus) ...
Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction
(2016-05-16)
Proper postsynaptic assembly is a fundamental requirement for circuit function, yet our understanding of its molecular mechanism is incomplete. The Drosophila neuromuscular junction is a powerful system for genetically ...
It Takes Brains: Germline and Somatic Mutations in Neurodevelopmental Disorders
(2016-05-05)
The human brain can be affected by many diseases during its development, and human genetics studies can illuminate the genetic etiology of these diseases, which is critical for understanding disease pathophysiology, improving ...
Lineage and Functional Analyses of Specific Subsets of Retinal Progenitor Cells
(2015-05-21)
The vertebrate central nervous system (CNS) is made up of a diverse array of cell types. The retina, an accessible part of the CNS with seven major cell types and more than sixty cell subtypes, is an excellent model system ...
An Anatomical and Functional Dissection of the Role Pet1 Raphe Neurons Play in Neonatal Cardiorespiratory Homeostasis
(2016-08-26)
Life-sustaining cardiorespiratory homeostasis requires the dynamic response of brainstem neural circuits. Apneas - the cessation of breathing often accompanied by bradycardia - can reflect defects in these circuits, and ...
α-Synuclein Induces Mitochondrial Dysfunction Through Spectrin and the Actin Cytoskeleton
(2018-09-16)
Abnormal accumulation of the cytoplasmic protein α-synuclein in vulnerable neurons and glial is a pathological hallmark of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, collectively termed ...
Dendrite Patterning as a Model for Self-Organizing Systems
(2018-01-05)
Biological systems self-organize into complex well-ordered structures and can evolve new patterns when perturbed. To identify principles underlying self-organization, I turned to the model organism C. elegans for its ...