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Mutation Induced Extinction in Finite Populations: Lethal Mutagenesis and Lethal Isolation
(Public Library of Science, 2012)
Reproduction is inherently risky, in part because genomic replication can introduce new mutations that are usually deleterious toward fitness. This risk is especially severe for organisms whose genomes replicate ...
Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability
(Public Library of Science, 2013)
Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10–20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen ...
A Universal Trend among Proteomes Indicates an Oily Last Common Ancestor
(Public Library of Science, 2012)
Despite progresses in ancestral protein sequence reconstruction, much needs to be unraveled about the nature of the putative last common ancestral proteome that served as the prototype of all extant lifeforms. Here, we ...