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Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
(2022-09-08)
Research into the genetic basis of human disease has progressed rapidly over the past 20 years. Genome-wide association studies have identified thousands of links between common variants and phenotypic outcomes. More ...
The role of RNA splicing factors in the regulation of longevity
(2021-11-16)
Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...
Development and validation of computational models for efficient design of biological sequences
(2022-01-10)
There is a huge surge of interest in designing a wide variety of proteins to use as molecular research tools and biotherapeutics - promising to revolutionize our capacity to design what we need at will. This is particularly ...
The structure, function, and evolution of the fern vascular system
(2022-06-29)
Nearly 425 million years ago land plants evolved novel tissues to move water and sugar more efficiently through their body. These conducting tissues, xylem and phloem, amplified mass flow rates by orders of magnitude, ...
Transcriptional Response and Immune Activation after Morphogen Signaling in Melanoma
(2022-06-06)
TGFb and Wnt developmental signaling pathways are commonly dysregulated in cancer; this includes melanoma, the deadliest form of skin cancer. These pathways terminate in signaling transcription factors (TFs) binding to ...
Phylogeny and genome evolution of the flowering plant clade Malpighiales
(2020-11-23)
The revolutionary advancements in phylogenetic theory and sequencing technology have revived hope of resolving recalcitrant relationships but also revealed the common nature of more complexed genome evolution that leads ...
Markov Chain Monte Carlo Sampling Algorithms in Neural Circuitry
(2022-06-03)
There is growing evidence that the nervous system is tuned and adapted to the sta- tistical properties of the sensory information from the surrounding environment and that it is possible that the brain performs some form ...
Regulatory consequences of variation in transcription factor-DNA binding
(2022-03-17)
Transcription factors bind to their target DNA sites in a sequence-specific manner, modulating gene expression, and playing important roles in development, body patterning, cellular differentiation, and stimuli response. ...
Structure, Function, and Engineering of Relaxin Hormones and Receptors
(2022-03-17)
The relaxin family peptide receptor 1 (RXFP1) and its agonist, relaxin-2, are of significant therapeutic interest in the areas of cardiovascular and fibrotic diseases. RXFP1 is a family A G protein-coupled receptor (GPCR), ...
O-GlcNAc modification of casein kinase 2 alpha alters the phosphoproteome
(2022-05-12)
Post-translational modifications govern protein function and are paramount to many
signaling networks in cells. How different post-translational modifications intersect to result in
complex signaling outcomes represents a ...