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In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

Arand, Julia; Spieler, David; Karius, Tommy; Branco, Miguel R.; Meilinger, Daniela; Meissner, Alexander; Jenuwein, Thomas; Xu, Guoliang; Leonhardt, Heinrich; Wolf, Verena; Walter, Jörn (Public Library of Science, 2012)

The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood. Here, we describe a comprehensive analysis of DNA methylation ...

Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle

Liu, Jianing; Hettmer, Simone; Milsom, Michael D.; Hofmann, Inga; Hua, Frederic; Miller, Christine; Bronson, Roderick Terry; Wagers, Amy Jo (Public Library of Science, 2012)

Myeloid sarcomas are extramedullary accumulations of immature myeloid cells that may present with or without evidence of pathologic involvement of the bone marrow or peripheral blood, and often coincide with or precede a ...

From Noncoding Variant to Phenotype via SORT1 at the 1p13 Cholesterol Locus

Musunuru, Kiran; Strong, Alanna; Frank-Kamenetsky, Maria; Lee, Noemi E.; Ahfeldt, Tim; Sachs, Katherine V.; Li, Xiaoyu; Li, Hui; Kuperwasser, Nicolas; Ruda, Vera M.; Pirruccello, James Paul; Muchmore, Brian; Prokunina-Olsson, Ludmila; Hall, Jennifer L.; Schadt, Eric E.; Morales, Carlos R.; Lund-Katz, Sissel; Phillips, Michael C.; Wong, Jamie; Cantley, William; Racie, Timothy; Ejebe, Kenechi G.; Orho-Melander, Marju; Melander, Olle; Koteliansky, Victor; Fitzgerald, Kevin; Krauss, Ronald M.; Cowan, Chad A.; Kathiresan, Sekar; Rader, Daniel J. (Springer Nature, 2010)

Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and myocardial infarction (MI) in humans. Here we ...

Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

Choudhuri, Avik; Trompouki, Eirini; Abraham, Brian J.; Colli, Leandro M.; Kock, Kian Hong; Mallard, William; Yang, Min-Lee; Vinjamur, Divya S.; Ghamari, Alireza; Sporrij, Audrey; Hoi, Karen; Hummel, Barbara; Boatman, Sonja; Chan, Victoria; Tseng, Sierra; Nandakumar, Satish K.; Yang, Song; Lichtig, Asher; Superdock, Michael; Grimes, Seraj N.; Bowman, Teresa V.; Zhou, Yi; Takahashi, Shinichiro; Joehanes, Roby; Cantor, Alan; Bauer, Daniel; Ganesh, Santhi K.; Rinn, John; Albert, Paul S.; Bulyk, Martha; Chanock, Stephen J.; Young, Richard; Zon, Leonard (Springer Science and Business Media LLC, 2020-11-23)

Genome-wide association studies (GWAS) reveal genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell type-specific enhancers, but the molecular mechanism by which ...