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Cationic Peptide Exposure Enhances Pulsed-Electric-Field-Mediated Membrane Disruption
(Public Library of Science, 2014)
Background: The use of pulsed electric fields (PEFs) to irreversibly electroporate cells is a promising approach for destroying undesirable cells. This approach may gain enhanced applicability if the intensity of the PEF ...
Endangered Right Whales Enhance Primary Productivity in the Bay of Fundy
(Public Library of Science, 2016)
Marine mammals have recently been documented as important facilitators of rapid and efficient nutrient recycling in coastal and offshore waters. Whales enhance phytoplankton nutrition by releasing fecal plumes near the ...
Angiotensin II Induced Cardiac Dysfunction on a Chip
(Public Library of Science, 2016)
In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ...
A Simulated Intermediate State for Folding and Aggregation Provides Insights into ΔN6 β2-Microglobulin Amyloidogenic Behavior
(Public Library of Science, 2014)
A major component of ex vivo amyloid plaques of patients with dialysis-related amyloidosis (DRA) is a cleaved variant of β2-microglobulin (ΔN6) lacking the first six N-terminal residues. Here we perform a computational ...
Peridynamic Modeling of Ruptures in Biomembranes
(Public Library of Science, 2016)
We simulate the formation of spontaneous ruptures in supported phospholipid double bilayer membranes, using peridynamic modeling. Experiments performed on spreading double bilayers typically show two distinct kinds of ...
Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling
(Public Library of Science, 2016)
The molecular complexity within a cell may be seen as an evolutionary response to the external complexity of the cell’s environment. This suggests that the external environment may be harnessed to interrogate the cell’s ...
Executive Function, Visual Attention and the Cocktail Party Problem in Musicians and Non-Musicians
(Public Library of Science, 2016)
The goal of this study was to investigate how cognitive factors influence performance in a multi-talker, “cocktail-party” like environment in musicians and non-musicians. This was achieved by relating performance in a ...
Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors
(Public Library of Science, 2016)
Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS). Idebenone and menadione ...
The Kinematics of Plant Nutation Reveals a Simple Relation between Curvature and the Orientation of Differential Growth
(Public Library of Science, 2016)
Nutation is an oscillatory movement that plants display during their development. Despite its ubiquity among plants movements, the relation between the observed movement and the underlying biological mechanisms remains ...
Benchmarking Inverse Statistical Approaches for Protein Structure and Design with Exactly Solvable Models
(Public Library of Science, 2016)
Inverse statistical approaches to determine protein structure and function from Multiple Sequence Alignments (MSA) are emerging as powerful tools in computational biology. However the underlying assumptions of the relationship ...