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Statistical Analysis of Molecular Signal Recording
(Public Library of Science, 2013)
A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) ...
Point Charges Optimally Placed to Represent the Multipole Expansion of Charge Distributions
(Public Library of Science, 2013)
We propose an approach for approximating electrostatic charge distributions with a small number of point charges to optimally represent the original charge distribution. By construction, the proposed optimal point charge ...
Dynamics in Biological Soft Materials
(2014-02-25)
I present applications of imaging and spectroscopy to understand mechanical, chemical, and electrical dynamics in biological materials. The first part describes the development and characterization of a protein-based ...
Chemical and Physical Determinants of Cell Migration
(2014-06-20)
The phenomenon of directed cell motion in response to external directional cues has drawn significant interest for more than a century, with the first recorded observations of bacterial chemotaxis at the end of the 19th ...
FRAP Analysis: Accounting for Bleaching during Image Capture
(Public Library of Science, 2012)
The analysis of Fluorescence Recovery After Photobleaching (FRAP) experiments involves mathematical modeling of the fluorescence recovery process. An important feature of FRAP experiments that tends to be ignored in the ...
Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability
(Public Library of Science, 2013)
Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10–20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen ...
The Mechanics of Fibrin Networks and Their Alterations by Platelets
(2013-09-04)
Fibrin is a biopolymer that assembles into a network during blood coagulation to become the structural scaffold of a blood clot. The precise mechanics of this network are crucial for a blood clot to properly stem the flow ...
Quantifying Patterns of Morphological Diversity
(2013-10-18)
One of the central questions of biology is how shape is formed by the interaction
3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing
(Public Library of Science, 2012)
The connectivity among neurons holds the key to understanding brain function. Mapping neural connectivity in brain circuits requires imaging techniques with high spatial resolution to facilitate neuron tracing and high ...
Angiotensin II Induced Cardiac Dysfunction on a Chip
(Public Library of Science, 2016)
In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ...